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Literature summary for 2.1.3.3 extracted from

  • He, L.; Cai, X.; Cheng, S.; Zhou, H.; Zhang, Z.; Ren, J.; Ren, F.; Yang, Q.; Tao, N.; Chen, J.
    Ornithine transcarbamylase downregulation is associated with poor prognosis in hepatocellular carcinoma (2019), Oncol. Lett., 17, 5030-5038 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.3.3

Application

Application Comment Organism
medicine enzyme downregulation is associated with poor prognosis in hepatocellular carcinoma Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
carbamoyl phosphate + L-ornithine Homo sapiens
-
 phosphate + L-citrulline
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEP-3B cell
-
 Homo sapiens
-
Hep-G2 cell
-
 Homo sapiens
-
hepatocyte
-
 Homo sapiens
-
hepatoma cell
-
 Homo sapiens
-
Huh-7 cell
-
 Homo sapiens
-
MIHA cell
-
 Homo sapiens
-
PLC-PRF-5 cell
-
 Homo sapiens
-
SK-HEP-1 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
carbamoyl phosphate + L-ornithine
-
 Homo sapiens phosphate + L-citrulline
-
 ?

Synonyms

Synonyms Comment Organism
ornithine transcarbamylase
-
 Homo sapiens
OTC
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens lower enzyme expression is observed in hepatocellular carcinoma cells and tissues compared with primary human hepatocytes down