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Literature summary for 2.1.3.3 extracted from

  • Van de Casteele, M.; Demarez, M.; Legrain, C.; Glansdorff, N.; Pierard, A.
    Pathways of arginine biosynthesis in extreme thermophilic archaeo- and eubacteria (1990), J. Gen. Microbiol., 136, 1177-1183.
No PubMed abstract available
Search for more literature for 2.1.3.3

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
carbamoyl phosphate + L-ornithine Saccharolobus solfataricus Sulfolobus solfataricus lacks ornithine acetyltransferase and thus forms N-acetylglutamate exclusively via the energetically less favourable reaction catalysed by N-acetylglutamate synthase, investing 1 mol of acetyl CoA per mol of N-acetyl intermediate synthesized phosphate + L-citrulline
-
 ?
carbamoyl phosphate + L-ornithine Saccharolobus solfataricus P1 Sulfolobus solfataricus lacks ornithine acetyltransferase and thus forms N-acetylglutamate exclusively via the energetically less favourable reaction catalysed by N-acetylglutamate synthase, investing 1 mol of acetyl CoA per mol of N-acetyl intermediate synthesized phosphate + L-citrulline
-
 ?

Organism

Organism UniProt Comment Textmining
Pyrococcus furiosus
-
-
-
Saccharolobus solfataricus
-
-
-
Saccharolobus solfataricus P1
-
-
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.12
-
 pH 8.0, 55°C, activity in cell culture in growth medium with 0.2% yeast extract Saccharolobus solfataricus
0.255
-
 pH 8.0, 55°C, activity in cell culture in minimal growth medium with 20 mM glucose and 5 mM NH4+ Saccharolobus solfataricus
0.43
-
 pH 8.0, 55°C, activity in cell culture in growth medium with 0.5% peptone and 0.1% yeast extract Pyrococcus furiosus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
carbamoyl phosphate + L-ornithine
-
 Pyrococcus furiosus phosphate + L-citrulline
-
 ?
carbamoyl phosphate + L-ornithine
-
 Saccharolobus solfataricus phosphate + L-citrulline
-
 ?
carbamoyl phosphate + L-ornithine Sulfolobus solfataricus lacks ornithine acetyltransferase and thus forms N-acetylglutamate exclusively via the energetically less favourable reaction catalysed by N-acetylglutamate synthase, investing 1 mol of acetyl CoA per mol of N-acetyl intermediate synthesized Saccharolobus solfataricus phosphate + L-citrulline
-
 ?
carbamoyl phosphate + L-ornithine
-
 Saccharolobus solfataricus P1 phosphate + L-citrulline
-
 ?
carbamoyl phosphate + L-ornithine Sulfolobus solfataricus lacks ornithine acetyltransferase and thus forms N-acetylglutamate exclusively via the energetically less favourable reaction catalysed by N-acetylglutamate synthase, investing 1 mol of acetyl CoA per mol of N-acetyl intermediate synthesized Saccharolobus solfataricus P1 phosphate + L-citrulline
-
 ?

Synonyms

Synonyms Comment Organism
ornithine carbamoyltransferase
-
 Pyrococcus furiosus
ornithine carbamoyltransferase
-
 Saccharolobus solfataricus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
55
-
 assay at Pyrococcus furiosus
55
-
 assay at Saccharolobus solfataricus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
 assay at Pyrococcus furiosus
8
-
 assay at Saccharolobus solfataricus

Expression

Organism Comment Expression
Pyrococcus furiosus threefold repression of enzyme formation by arginine additional information
Saccharolobus solfataricus threefold repression of enzyme formation by arginine additional information

General Information

General Information Comment Organism
metabolism Sulfolobus solfataricus lacks ornithine acetyltransferase and thus forms N-acetylglutamate exclusively via the energetically less favourable reaction catalysed by N-acetylglutamate synthase, investing 1 mol of acetyl CoA per mol of N-acetyl intermediate synthesized Saccharolobus solfataricus