Literature summary for 2.1.3.3 extracted from

Bensemain, F.; Hot, D.; Ferreira, S.; Dumont, J.; Bombois, S.; Maurage, C.; Huot, L.; Hermant, X.; Levillain, E.; Hubans, C.; Hansmannel, F.; Chapuis, J.; Hauw, J.; Schraen, S.; Lemoine, Y.; Buee, L.; Berr, C.; Mann, D.; Pasquier, F.; Amouyel, P.; Lambert, J.C.
Evidence for induction of the ornithine transcarbamylase expression in Alzheimers disease (2009), Mol. Psychiatry, 14, 106-116.

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Application

Application	Comment	Organism
medicine	in patients with Alzheimer's disease, ornithine carbamoyltransferase is expressed in brain, but not in controls. Ornithine carbamoyltransferase expression is strictly restricted to vascular endothelial cells. Ornithine carbamoyltransferase activity is 880% increased in the cerebrospinal fluid of probable Alzheimer's disease cases compared with controls. Rare haplotypes may be associated with the risk of Alzheimer's disease through a possible modulation of the methylation of the ornithine carbamoyltransferase promoter	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	patients with Alzheimer's disease	-

Expression

Organism	Comment	Expression
Homo sapiens	in patients with Alzheimer's disease, ornithine carbamoyltransferase is expressed in brain, but not in controls. Ornithine carbamoyltransferase expression is strictly restricted to vascular endothelial cells. Ornithine carbamoyltransferase activity is 880% increased in the cerebrospinal fluid of probable Alzheimer's disease cases compared with controls. Rare haplotypes may be associated with the risk of Alzheimer's disease through a possible modulation of the methylation of the ornithine carbamoyltransferase promoter	up

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Release 2023.1 (January 2023)