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Literature summary for 2.1.3.2 extracted from
- carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase (cad) regulates Notch signaling and vascular development in zebrafish (2015), Dev. Dyn., 244, 1-9.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Danio rerio | CAD is a rate-limiting enzyme required for the formation of UDP sugar, upstream of two different metabolic pathways; the de novo biosynthesis of pyrimidine and pyrimide-based nucleotides, and the formation of UDP sugar intermediates, required for UDP-dependent glycosylation events | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Danio rerio | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | CAD is a rate-limiting enzyme required for the formation of UDP sugar, upstream of two different metabolic pathways; the de novo biosynthesis of pyrimidine and pyrimide-based nucleotides, and the formation of UDP sugar intermediates, required for UDP-dependent glycosylation events | Danio rerio | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| aspartate transcarbamylase | - |
Danio rerio |
| CAD | - |
Danio rerio |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | a missense mutation in the carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase (cad) gene causes reduced lymphatic vessel development. The mutant also exhibits hyperbranching arteries, reminiscent of Notch pathway mutants. Notch signaling is significantly reduced in cadhu10125 mutants. hu10125 mutants display reduced formation of the thoracic duct and hyperbranched intersegmental arteries, penotype, overview | Danio rerio |
| physiological function | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase form the CAD complex that is essential for UDP biosynthesis, which is necessary for protein glycosylation and de novo biosynthesis of pyrimidine-based nucleotides. CAD is an unappreciated mechanism that regulates Notch/Vegf signaling during angiogenesis | Danio rerio |
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