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Literature summary for 2.1.3.2 extracted from
- Aspartate transcarbamylase from Streptococcus faecalis. Steady-state kinetic analysis (1974), Biochemistry, 13, 638-645.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| carbamoyl aspartate | - |
Enterococcus faecalis |  |
| carbamoylaspartate | - |
Enterococcus faecalis | |
| diphosphate | - |
Enterococcus faecalis | |
| Maleate | - |
Enterococcus faecalis | |
| phosphate | - |
Enterococcus faecalis | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0077 | - |
Carbamoyl phosphate | - |
Enterococcus faecalis | |
| 10 | - |
L-aspartate | - |
Enterococcus faecalis | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| carbamoylphosphate + L-aspartate | Enterococcus faecalis | - |
phosphate + N-carbamoyl-L-aspartate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Enterococcus faecalis | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Enterococcus faecalis |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate | reaction mechanism | Enterococcus faecalis |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| carbamoyl phosphate + L-aspartate | - |
Enterococcus faecalis | phosphate + N-carbamoyl-L-aspartate | - |
? | |
| carbamoylphosphate + L-aspartate | - |
Enterococcus faecalis | phosphate + N-carbamoyl-L-aspartate | - |
? | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.9 | - |
diphosphate | competitive vs. carbamoyl phosphate | Enterococcus faecalis | |
| 1 | - |
Maleate | competitive vs. L-aspartate | Enterococcus faecalis | |
| 5 | - |
phosphate | competitive vs. carbamoyl phosphate | Enterococcus faecalis | |
| 7 | - |
carbamoyl aspartate | competitive vs. carbamoyl phosphate | Enterococcus faecalis | |
| 13 | - |
carbamoylaspartate | noncompetitive vs. carbamoyl phosphate | Enterococcus faecalis | |
| 14 | - |
phosphate | competitive vs. L-aspartate | Enterococcus faecalis | |
| 15 | - |
carbamoyl aspartate | competitive vs. L-aspartate | Enterococcus faecalis | |
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