Synthesis and characterization of a BODIPY-labeled derivative of Soraphen A that binds to acetyl-CoA carboxylase

Raymer, B.; Kavana, M.; Price, A.; Wang, B.; Corcoran, L.; Kulathila, R.; Groarke, J.; Mann, T.; Bioorg. Med. Chem. Lett. 19, 2804-2807 (2009)

Data extracted from this reference:

Inhibitors

Commentary

Organism

Structure

4,4-difluoro-4-bora-3a,4a-diaza-s-indacene-labeled soraphen A

-

Homo sapiens

Natural Substrates

Organism

Commentary (Nat. Sub.)

Natural Products

Commentary (Nat. Pro.)

Organism (Nat. Pro.)

Reversibility

ID

[biotin carboxyl-carrier protein]-N6-carboxybiotinyl-L-lysine + acetyl-CoA

Homo sapiens

-

[biotin carboxyl-carrier protein]-N6-biotinyl-L-lysine + malonyl-CoA

-

-

?

Substrates

Commentary Substrates

Literature (Substrates)

Organism

Products

Commentary (Products)

Literature (Products)

Organism (Products)

Reversibility

Substrate Product ID

[biotin carboxyl-carrier protein]-N6-carboxybiotinyl-L-lysine + acetyl-CoA

-

744496

Homo sapiens

[biotin carboxyl-carrier protein]-N6-biotinyl-L-lysine + malonyl-CoA

-

-

-

?

Inhibitors

Commentary

Organism

Structure

4,4-difluoro-4-bora-3a,4a-diaza-s-indacene-labeled soraphen A

-

Homo sapiens

Natural Substrates

Organism

Commentary (Nat. Sub.)

Natural Products

Commentary (Nat. Pro.)

Organism (Nat. Pro.)

Reversibility

ID

[biotin carboxyl-carrier protein]-N6-carboxybiotinyl-L-lysine + acetyl-CoA

Homo sapiens

-

[biotin carboxyl-carrier protein]-N6-biotinyl-L-lysine + malonyl-CoA

-

-

?

Substrates

Commentary Substrates

Literature (Substrates)

Organism

Products

Commentary (Products)

Literature (Products)

Organism (Products)

Reversibility

ID

[biotin carboxyl-carrier protein]-N6-carboxybiotinyl-L-lysine + acetyl-CoA

-

744496

Homo sapiens

[biotin carboxyl-carrier protein]-N6-biotinyl-L-lysine + malonyl-CoA

-

-

-

?

No.

1st author

Pub Med

title

organims

journal

volume

pages

year

Activating Compound

Application

Cloned(Commentary)

Crystallization (Commentary)

Engineering

General Stability

Inhibitors

KM Value [mM]

Localization

Metals/Ions

Molecular Weight [Da]

Natural Substrates/ Products (Substrates)

Organic Solvent Stability

Organism

Oxidation Stability

Posttranslational Modification

Purification (Commentary)

Reaction

Renatured (Commentary)

Source Tissue

Specific Activity [micromol/min/mg]

Storage Stability

Substrates and Products (Substrate)

Subunits

Synonyms

Temperature Optimum [°C]

Temperature Range [°C]

Temperature Stability [°C]

Turnover Number [1/s]

pH Optimum

pH Range

pH Stability

Cofactor

Ki Value [mM]

pI Value

IC50 Value

Activating Compound (protein specific)

Application (protein specific)

Cloned(Commentary) (protein specific)

Cofactor (protein specific)

Crystallization (Commentary) (protein specific)

Engineering (protein specific)

General Stability (protein specific)

IC50 Value (protein specific)

Inhibitors (protein specific)

Ki Value [mM] (protein specific)

KM Value [mM] (protein specific)

Localization (protein specific)

Metals/Ions (protein specific)

Molecular Weight [Da] (protein specific)

Natural Substrates/ Products (Substrates) (protein specific)

Organic Solvent Stability (protein specific)

Oxidation Stability (protein specific)

Posttranslational Modification (protein specific)

Purification (Commentary) (protein specific)

Renatured (Commentary) (protein specific)

Source Tissue (protein specific)

Specific Activity [micromol/min/mg] (protein specific)

Storage Stability (protein specific)

Substrates and Products (Substrate) (protein specific)

Subunits (protein specific)

Temperature Optimum [°C] (protein specific)

Temperature Range [°C] (protein specific)

Temperature Stability [°C] (protein specific)

Turnover Number [1/s] (protein specific)

pH Optimum (protein specific)

pH Range (protein specific)

pH Stability (protein specific)

pI Value (protein specific)

Expression

General Information

General Information (protein specific)

Expression (protein specific)

KCat/KM [mM/s]

KCat/KM [mM/s] (protein specific)

758056

Shivaiah

Non-catalytic subunits facili ...

Arabidopsis thaliana

Plant Physiol.

182

756-775

2020

1

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1

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758050

Keereetaweep

Biotin attachment domain-cont ...

Arabidopsis thaliana

Plant Physiol.

177

208-215

2018

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-

-

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3

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744173

Evans

Acetyl-CoA carboxylase from E ...

Escherichia coli

Arch. Biochem. Biophys.

636

100-109

2017

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1

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758409

Pawelczyk

The influence of AccD5 on Acc ...

Mycobacterium tuberculosis, Mycolicibacterium smegmatis, Mycobacterium tuberculosis H37Rv, Mycolicibacterium smegmatis mc(2)155

Sci. Rep.

7

42692

2017

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756040

Silvers

Crystal structure of carboxyl ...

Staphylococcus aureus

Biochemistry

55

4666-4674

2016

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-

1

1

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5

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744336

Broussard

Structural analysis of substr ...

Haemophilus influenzae

Biochemistry

54

3860-3870

2015

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744496

Raymer

Synthesis and characterizatio ...

Homo sapiens

Bioorg. Med. Chem. Lett.

19

2804-2807

2009

-

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1

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744305

Bilder

The structure of the carboxyl ...

Staphylococcus aureus, Escherichia coli

Biochemistry

45

1712-1722

2006

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2

2

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745266

Blanchard

The biotin domain peptide fro ...

Escherichia coli

J. Biol. Chem.

274

31767-31769

1999

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