Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.1.2.8 extracted from

  • Allen, J.R.; Lasser, G.W.; Goldman, D.A.; Booth, J.W.; Mathews, C.K.
    T4 phage deoxyribonucleotide-synthesizing enzyme complex. Further studies on enzyme composition and regulation (1983), J. Biol. Chem., 258, 5746-5753.
    View publication on PubMed
Search for more literature for 2.1.2.8

Cloned(Commentary)

Cloned (Comment) Organism
structural gene 42 encodes enzyme Tequatrovirus T4

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
27000
-
 2 * 27000 Tequatrovirus T4
60000
-
-
 Tequatrovirus T4

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5,10-methylenetetrahydrofolate + H2O + deoxycytidylate Tequatrovirus T4 dCTP depresses the synthesis of 5-hydroxymethyldeoxycytidylate tetrahydrofolate + 5-hydroxymethyldeoxycytidylate
-
 ?
additional information Tequatrovirus T4 enzyme is part of a complex efficiently channeling DNA precursors to the replication apparatus ?
-
 ?

Organism

Organism UniProt Comment Textmining
Tequatrovirus T4
-
 Escherichia coli infected with bacteriophage T4
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5,10-methylenetetrahydrofolate + H2O + deoxycytidylate
-
 Tequatrovirus T4 tetrahydrofolate + 5-hydroxymethyldeoxycytidylate
-
 ?
5,10-methylenetetrahydrofolate + H2O + deoxycytidylate dCTP depresses the synthesis of 5-hydroxymethyldeoxycytidylate Tequatrovirus T4 tetrahydrofolate + 5-hydroxymethyldeoxycytidylate
-
 ?
additional information enzyme is part of a complex efficiently channeling DNA precursors to the replication apparatus Tequatrovirus T4 ?
-
 ?

Subunits

Subunits Comment Organism
dimer 2 * 27000 Tequatrovirus T4

Cofactor

Cofactor Comment Organism Structure
5,10-methylenetetrahydrofolate
-
 Tequatrovirus T4
tetrahydrofolate
-
 Tequatrovirus T4