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Literature summary for 2.1.2.3 extracted from

  • Boutchueng-Djidjou, M.; Collard-Simard, G.; Fortier, S.; Hebert, S.S.; Kelly, I.; Landry, C.R.; Faure, R.L.
    The last enzyme of the de novo purine synthesis pathway 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC) plays a central role in insulin signaling and the Golgi/endosomes protein network (2015), Mol. Cell. Proteomics, 14, 1079-1092.
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining
endosome the enzyme later accumulates in the Golgi/endosome network Homo sapiens 5768
-
endosome the enzyme later accumulates in the Golgi/endosome network Rattus norvegicus 5768
-
Golgi apparatus the enzyme later accumulates in the Golgi/endosome network Homo sapiens 5794
-
Golgi apparatus the enzyme later accumulates in the Golgi/endosome network Rattus norvegicus 5794
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide Homo sapiens
-
tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
-
?
10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide Rattus norvegicus
-
tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
-
?
additional information Homo sapiens the enzyme forms a complex with its substrate via the phosphate-binding pocket of the IMP cyclohydrolase (IMPCH) domain (residues 1-599) ?
-
?
additional information Rattus norvegicus the enzyme forms a complex with its substrate via the phosphate-binding pocket of the IMP cyclohydrolase (IMPCH) domain (residues 1-599) ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P31939
-
-
Rattus norvegicus Q6IN16
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
-
Homo sapiens
-
liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
-
Homo sapiens tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
-
?
10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
-
Rattus norvegicus tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
-
?
additional information the enzyme forms a complex with its substrate via the phosphate-binding pocket of the IMP cyclohydrolase (IMPCH) domain (residues 1-599) Homo sapiens ?
-
?
additional information the enzyme forms a complex with its substrate via the phosphate-binding pocket of the IMP cyclohydrolase (IMPCH) domain (residues 1-599) Rattus norvegicus ?
-
?

Synonyms

Synonyms Comment Organism
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
-
Homo sapiens
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
-
Rattus norvegicus
ATIC
-
Homo sapiens
ATIC
-
Rattus norvegicus
Bifunctional purine biosynthesis protein
-
Homo sapiens
Bifunctional purine biosynthesis protein
-
Rattus norvegicus
PurH
-
Homo sapiens
PurH
-
Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
10-formyltetrahydrofolate
-
Homo sapiens
10-formyltetrahydrofolate
-
Rattus norvegicus

General Information

General Information Comment Organism
malfunction insulin stimulation and enzyme ATIC knockdown readily increase the level of AMP-activated protein kinase-Thr172 phosphorylation in insulin receptor complexes. Enzyme ATIC, protein-tyrosine phosphatase-like A domain-containing protein 1, and AMP-activated protein kinase knockdown affects insulin receptor internalization in HEK-293 cells Homo sapiens
malfunction insulin stimulation and enzyme ATIC knockdown readily increase the level of AMPK-Thr172 phosphorylation in insulin receptor complexes Rattus norvegicus
metabolism last and rate-limiting enzyme of the de novo purine synthesis pathway Homo sapiens
metabolism last and rate-limiting enzyme of the de novo purine synthesis pathway Rattus norvegicus
additional information 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide is a is a potent allosteric AMPK activator Homo sapiens
additional information 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide is a is a potent allosteric AMPK activator. Insulin receptor autophosphorylation in isolated endosomes incubated in the presence of purified enzyme ATIC Rattus norvegicus
physiological function the enzyme 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase plays a central role in insulin signaling and the Golgi/endosomes protein network, compartmentalization in vivo of involved enzymes in response to insulin, kinetics of the localization, overview Homo sapiens
physiological function the enzyme 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase plays a central role in insulin signaling and the Golgi/endosomes protein network, compartmentalization in vivo of involved enzymes in response to insulin, kinetics of the localization, overview Rattus norvegicus