Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endosome | the enzyme later accumulates in the Golgi/endosome network | Homo sapiens | 5768 | - |
endosome | the enzyme later accumulates in the Golgi/endosome network | Rattus norvegicus | 5768 | - |
Golgi apparatus | the enzyme later accumulates in the Golgi/endosome network | Homo sapiens | 5794 | - |
Golgi apparatus | the enzyme later accumulates in the Golgi/endosome network | Rattus norvegicus | 5794 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide | Homo sapiens | - |
tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide | - |
? | |
10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide | Rattus norvegicus | - |
tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide | - |
? | |
additional information | Homo sapiens | the enzyme forms a complex with its substrate via the phosphate-binding pocket of the IMP cyclohydrolase (IMPCH) domain (residues 1-599) | ? | - |
? | |
additional information | Rattus norvegicus | the enzyme forms a complex with its substrate via the phosphate-binding pocket of the IMP cyclohydrolase (IMPCH) domain (residues 1-599) | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P31939 | - |
- |
Rattus norvegicus | Q6IN16 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293 cell | - |
Homo sapiens | - |
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide | - |
Homo sapiens | tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide | - |
? | |
10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide | - |
Rattus norvegicus | tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide | - |
? | |
additional information | the enzyme forms a complex with its substrate via the phosphate-binding pocket of the IMP cyclohydrolase (IMPCH) domain (residues 1-599) | Homo sapiens | ? | - |
? | |
additional information | the enzyme forms a complex with its substrate via the phosphate-binding pocket of the IMP cyclohydrolase (IMPCH) domain (residues 1-599) | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase | - |
Homo sapiens |
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase | - |
Rattus norvegicus |
ATIC | - |
Homo sapiens |
ATIC | - |
Rattus norvegicus |
Bifunctional purine biosynthesis protein | - |
Homo sapiens |
Bifunctional purine biosynthesis protein | - |
Rattus norvegicus |
PurH | - |
Homo sapiens |
PurH | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
10-formyltetrahydrofolate | - |
Homo sapiens | |
10-formyltetrahydrofolate | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
malfunction | insulin stimulation and enzyme ATIC knockdown readily increase the level of AMP-activated protein kinase-Thr172 phosphorylation in insulin receptor complexes. Enzyme ATIC, protein-tyrosine phosphatase-like A domain-containing protein 1, and AMP-activated protein kinase knockdown affects insulin receptor internalization in HEK-293 cells | Homo sapiens |
malfunction | insulin stimulation and enzyme ATIC knockdown readily increase the level of AMPK-Thr172 phosphorylation in insulin receptor complexes | Rattus norvegicus |
metabolism | last and rate-limiting enzyme of the de novo purine synthesis pathway | Homo sapiens |
metabolism | last and rate-limiting enzyme of the de novo purine synthesis pathway | Rattus norvegicus |
additional information | 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide is a is a potent allosteric AMPK activator | Homo sapiens |
additional information | 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide is a is a potent allosteric AMPK activator. Insulin receptor autophosphorylation in isolated endosomes incubated in the presence of purified enzyme ATIC | Rattus norvegicus |
physiological function | the enzyme 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase plays a central role in insulin signaling and the Golgi/endosomes protein network, compartmentalization in vivo of involved enzymes in response to insulin, kinetics of the localization, overview | Homo sapiens |
physiological function | the enzyme 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase plays a central role in insulin signaling and the Golgi/endosomes protein network, compartmentalization in vivo of involved enzymes in response to insulin, kinetics of the localization, overview | Rattus norvegicus |