Application | Comment | Organism |
---|---|---|
medicine | target for development of inhibitors with potential use as chemotherapeutic agents | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
cloned from a placenta cDNA library, overproduced in Escherichia coli | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-amino-10-methylpteroylglutamic acid | methotrexate, non-competitive inhibitor | Homo sapiens | |
dihydrofolic acid pentaglutamate | - |
Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
65000 | - |
recombinant enzyme, SDS-PAGE | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide | Salmonella enterica subsp. enterica serovar Typhimurium | - |
tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide | - |
r | |
10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide | Bacillus subtilis | - |
tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide | - |
r | |
10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide | Homo sapiens | penultimate and final steps in the de novo purine biosynthesis pathway | tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bacillus subtilis | - |
- |
- |
Homo sapiens | - |
human | - |
Salmonella enterica subsp. enterica serovar Typhimurium | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
CCRF-CEM cell | leukemia cell, T lymphoblastoid cell line | Homo sapiens | - |
HeLa cell | cervical carcinoma cell line | Homo sapiens | - |
Hep-G2 cell | hepatocellular carcinoma cell line | Homo sapiens | - |
liver | - |
Homo sapiens | - |
placenta | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide | - |
Salmonella enterica subsp. enterica serovar Typhimurium | tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide | - |
r | |
10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide | - |
Bacillus subtilis | tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide | - |
r | |
10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide | penultimate and final steps in the de novo purine biosynthesis pathway | Homo sapiens | tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide | - |
r | |
additional information | in all organisms studied to date AICARFT activity is accompanied by inosine monophosphate cyclohydrolase located on the same polypeptide encoded by the purH gene | Salmonella enterica subsp. enterica serovar Typhimurium | ? | - |
? | |
additional information | in all organisms studied to date AICARFT activity is accompanied by inosine monophosphate cyclohydrolase located on the same polypeptide encoded by the purH gene | Bacillus subtilis | ? | - |
? | |
additional information | in all organisms studied to date AICARFT activity is accompanied by inosine monophosphate cyclohydrolase located on the same polypeptide encoded by the purH gene | Homo sapiens | ? | - |
? | |
N10-formyltetrahydrofolic acid + 5-amino-4-imidazole carboxamide ribonucleotide | - |
Salmonella enterica subsp. enterica serovar Typhimurium | tetrahydrofolic acid + 5-formamido-4-imidazole carboxamide ribonucleotide | - |
r | |
N10-formyltetrahydrofolic acid + 5-amino-4-imidazole carboxamide ribonucleotide | - |
Bacillus subtilis | tetrahydrofolic acid + 5-formamido-4-imidazole carboxamide ribonucleotide | - |
r | |
N10-formyltetrahydrofolic acid + 5-amino-4-imidazole carboxamide ribonucleotide | - |
Homo sapiens | tetrahydrofolic acid + 5-formamido-4-imidazole carboxamide ribonucleotide | - |
r |