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Literature summary for 2.1.2.3 extracted from
- Biosynthesis of the purines. XXVI. The Identification of the formyl donors of the transformylation reactions (1959), J. Biol. Chem., 234, 1812-1816.
General Stability
| General Stability | Organism |
|---|---|
| much less stable during storage in maleate buffer than in Tris or phosphate solutions | Gallus sp. |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Cu2+ | - |
Gallus sp. |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide | Gallus sp. | precursors for inosinic acid biosynthesis | tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Gallus sp. | - |
chicken | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Gallus sp. |
Storage Stability
| Storage Stability | Organism |
|---|---|
| 2°C, if the solution of purified enzyme are stored for 3 or 4 months, a requirement for a specific formyl donor can then be shown | Gallus sp. |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide | precursors for inosinic acid biosynthesis | Gallus sp. | tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide | - |
r | |
| additional information | in all organisms studied to date AICARFT activity is accompanied by inosine monophosphate cyclohydrolase located on the same polypeptide encoded by the purH gene | Gallus sp. | ? | - |
? | |
| N10-formyltetrahydrofolic acid + 5-amino-4-imidazole carboxamide ribonucleotide | - |
Gallus sp. | tetrahydrofolic acid + 5-formamido-4-imidazole carboxamide ribonucleotide | - |
r | |
| N5,N10-anhydroformyltetrahydrofolic acid + glycinamide ribonucleotide | - |
Gallus sp. | N10-formyltetrahydrofolic acid + formylglycinamide ribonucleotide | - |
r | |
| tetrahydrofolic acid + 5-formamido-4-imidazole carboxamide ribonucleotide | - |
Gallus sp. | N10-formyltetrahydrofolic acid + 5-amino-4-imidazole carboxamide ribonucleotide | - |
r | |
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