Any feedback?
Literature summary for 2.1.2.2 extracted from
- Increased expression of glycinamide ribonucleotide transformylase is associated with a poor prognosis in hepatocellular carcinoma, and it promotes liver cancer cell proliferation (2014), Hum. Pathol., 45, 1370-1378.
Application
| Application | Comment | Organism |
|---|---|---|
| diagnostics | increased expression of glycinamide ribonucleotide transformylase is associated with a poor prognosis in hepatocellular carcinoma | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| enzyme expression analysis in hepatocellular carcinoma cell lines, overview | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | enzyme knockdown by siRNA | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P22102 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| BEL-7404 cell | - |
Homo sapiens | - |
| Hep-G2 cell | - |
Homo sapiens | - |
| hepatocellular carcinoma cell | enzyme expression and functional significance in hepatocellular carcinoma cells from several patients, overview | Homo sapiens | - |
| Huh-7 cell | - |
Homo sapiens | - |
| MHCC97H cell | - |
Homo sapiens | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| GART | - |
Homo sapiens |
| glycinamide ribonucleotide transformylase | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | depletion of the enzyme by small interfering RNA inhibits cell proliferation and blocks S-phase and mitotic entry in cultured Hep-G2 and BEL-7404 cells. Enzyme depletion decreases the proliferating cell nuclear antigen concentration | Homo sapiens |
| metabolism | glycinamide ribonucleotide transformylase is a folate-dependent enzyme in the de novo purine pathway | Homo sapiens |
| physiological function | increased expression of glycinamide ribonucleotide transformylase promotes liver cancer cell proliferation, enzyme expression and functional significance in hepatocellular carcinoma cells from several patients, overview | Homo sapiens |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
