Cloned (Comment) | Organism |
---|---|
hybrid enzymes of human GART and PurN from Escherichia coli are expressed in Escherichia coli: PGX-B12 (PurN1-101/hGART102-202), GPX-M1 (hGART1-100/PurN101-212), GPX-M1 (hGART1129/PurN54-212), GPX-M24 (hGART1-54/PurN55-212), GPX-M36 (hGART1-89/PurN90-212), GPX-M55 (hGART1-56/PurN58-212), GPG-N11 (hGART1-56/PurN57-131/hGART132-202) | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | hybrid enzymes of human GART and PurN from Escherichia coli are expressed in Escherichia coli: PGX-B12 (PurN1-101/hGART102-202),GPX-M1 (hGART1-100/PurN101-212), GPX-M1 (hGART1129/PurN54-212), GPX-M24 (hGART1-54/PurN55-212), GPX-M36 (hGART1-89/PurN90-212), GPX-M55 (hGART1-56/PurN58-212), GPG-N11 (hGART1-56/PurN57-131/hGART132-202) | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.99 | - |
beta-glycinamide ribonucleotide | chimeric enzyme GPG-N11 (hGART1-56/PurN57-131/hGART132-202) | Homo sapiens | |
0.99 | - |
10-formyl-5,8-dideazafolate | chimeric enzyme GPG-N11 (hGART1-56/PurN57-131/hGART132-202) | Homo sapiens | |
4 | - |
beta-glycinamide ribonucleotide | wild-type enzyme | Homo sapiens | |
4 | - |
10-formyl-5,8-dideazafolate | wild-type enzyme | Homo sapiens | |
4 | - |
beta-glycinamide ribonucleotide | chimeric enzyme GPX-M1 (hGART1-100/PurN101-212) | Homo sapiens | |
4 | - |
10-formyl-5,8-dideazafolate | chimeric enzyme GPX-M1 (hGART1-100/PurN101-212) | Homo sapiens | |
12 | - |
beta-glycinamide ribonucleotide | chimeric enzyme GPX-M55 (hGART1-56/PurN58-212) | Homo sapiens | |
12 | - |
10-formyl-5,8-dideazafolate | chimeric enzyme GPX-M55 (hGART1-56/PurN58-212) | Homo sapiens | |
21 | - |
beta-glycinamide ribonucleotide | chimeric enzyme GPX-M24 (hGART1-54/PurN55-212) | Homo sapiens | |
21 | - |
10-formyl-5,8-dideazafolate | chimeric enzyme GPX-M24 (hGART1-54/PurN55-212) | Homo sapiens | |
33 | - |
beta-glycinamide ribonucleotide | chimeric enzyme PGX-B12 (PurN1-101/hGART102-202) | Homo sapiens | |
33 | - |
10-formyl-5,8-dideazafolate | chimeric enzyme PGX-B12 (PurN1-101/hGART102-202) | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
10-formyl-5,8-dideazafolate + beta-glycinamide ribonucleotide | - |
Homo sapiens | 5,8-dideazafolate + N-formyl beta-glycinamide ribonucleotide | - |
? |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0019 | - |
10-formyl-5,8-dideazafolate | chimeric enzyme GPX-M1 (hGART1-100/PurN101-212) | Homo sapiens | |
0.0034 | - |
beta-glycinamide ribonucleotide | wild-type enzyme | Homo sapiens | |
0.0059 | - |
10-formyl-5,8-dideazafolate | wild-type enzyme | Homo sapiens | |
0.018 | - |
10-formyl-5,8-dideazafolate | chimeric enzyme GPX-M24 (hGART1-54/PurN55-212) | Homo sapiens | |
0.0262 | - |
beta-glycinamide ribonucleotide | chimeric enzyme PGX-B12 (PurN1-101/hGART102-202) | Homo sapiens | |
0.031 | - |
10-formyl-5,8-dideazafolate | chimeric enzyme GPX-M55 (hGART1-56/PurN58-212) | Homo sapiens | |
0.043 | - |
10-formyl-5,8-dideazafolate | chimeric enzyme GPG-N11 (hGART1-56/PurN57-131/hGART132-202) | Homo sapiens | |
0.0662 | - |
beta-glycinamide ribonucleotide | chimeric enzyme GPX-M1 (hGART1-100/PurN101-212) | Homo sapiens | |
0.102 | - |
10-formyl-5,8-dideazafolate | chimeric enzyme PGX-B12 (PurN1-101/hGART102-202) | Homo sapiens | |
0.262 | - |
beta-glycinamide ribonucleotide | chimeric enzyme GPX-M24 (hGART1-54/PurN55-212) | Homo sapiens | |
0.293 | - |
beta-glycinamide ribonucleotide | chimeric enzyme GPG-N11 (hGART1-56/PurN57-131/hGART132-202) | Homo sapiens | |
0.63 | - |
beta-glycinamide ribonucleotide | chimeric enzyme GPX-M55 (hGART1-56/PurN58-212) | Homo sapiens |