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Literature summary for 2.1.2.2 extracted from
- Mammalian glycinamide ribonucleotide transformylase. Kinetic mechanism and associated de novo purine biosynthesis activities (1989), J. Biol. Chem., 264, 5053-5057.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | pharmacological importance, target enzyme for chemotherapy, development of novel antifolate drugs, to be used as anti-cancer drugs | Mus musculus |
| medicine | pharmacological importance, target enzyme for chemotherapy, development of novel antifolate drugs, to be used as anti-cancer drugs | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 10-Acetyl-5,8-dideazafolate | - |
Drosophila melanogaster |  |
| 10-Acetyl-5,8-dideazafolate | - |
Homo sapiens | |
| 10-Acetyl-5,8-dideazafolate | - |
Mus musculus | |
| 5,10-dideazafolic acid | - |
Mus musculus | |
| alpha,beta-hydroxyacetamideribonucleotide | - |
Mus musculus | |
| alpha,beta-N-(hydroxyacetyl)-D-ribofuranosylamine | - |
Mus musculus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 110000 | - |
- |
Gallus gallus |
| 112000 | - |
HeLa and L1210 cells | Homo sapiens |
| 115000 | - |
- |
Mus musculus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide | Gallus gallus | essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway | tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide | - |
? | |
| 10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide | Drosophila melanogaster | essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway | tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide | - |
? | |
| 10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide | Mus musculus | essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway | tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide | - |
? | |
| 10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide | Homo sapiens | essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway | tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Drosophila melanogaster | - |
fruit fly | - |
| Gallus gallus | - |
chicken | - |
| Homo sapiens | - |
human | - |
| Mus musculus | - |
mouse | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Mus musculus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| L-5178-Y cell | murine lymphoma cell line | Mus musculus | - |
| liver | - |
Gallus gallus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide | - |
Gallus gallus | tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide | - |
? | |
| 10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide | - |
Drosophila melanogaster | tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide | - |
? | |
| 10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide | - |
Mus musculus | tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide | - |
? | |
| 10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide | - |
Homo sapiens | tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide | - |
? | |
| 10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide | essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway | Gallus gallus | tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide | - |
? | |
| 10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide | essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway | Drosophila melanogaster | tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide | - |
? | |
| 10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide | essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway | Mus musculus | tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide | - |
? | |
| 10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide | essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway | Homo sapiens | tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide | - |
? | |
| 10-formyltetrahydrofolate + carbocyclic beta-glycinamide ribonucleotide | - |
Gallus gallus | tetrahydrofolate + formyl glycinamide ribonucleotide | - |
? | |
| 10-formyltetrahydrofolate + carbocyclic beta-glycinamide ribonucleotide | - |
Mus musculus | tetrahydrofolate + formyl glycinamide ribonucleotide | - |
? | |
| 10-formyltetrahydrofolate + carbocyclic beta-glycinamide ribonucleotide | - |
Homo sapiens | tetrahydrofolate + formyl glycinamide ribonucleotide | - |
? | |
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