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Literature summary for 2.1.2.2 extracted from

  • Caperelli, C.A.
    Mammalian glycinamide ribonucleotide transformylase: Purification and some properties (1985), Biochemistry, 24, 1316-1320.
    View publication on PubMed

Application

Application Comment Organism
medicine pharmacological importance, target enzyme for chemotherapy, development of novel antifolate drugs, to be used as anti-cancer drugs Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00025
-
10-formyl-5,8-dideazafolate
-
Mus musculus
0.0008
-
L-(-)-10-formyltetrahydrofolate
-
Mus musculus
0.0019
-
10-formyl-5,8-dideazafolate
-
Gallus gallus
0.4
-
glycinamide ribonucleotide
-
Mus musculus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
61000
-
2 * 61000, SDS-PAGE Gallus gallus
102000
-
1 * 102000, SDS-PAGE Mus musculus
110000
-
1 * 110000, SDS-PAGE Mus musculus
125000
-
sucrose density gradient ultracentrifugation Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide Mus musculus in ureotelic animals such as mammals the role of the far less active pathway is to provide purine nucleotides for further anabolic sequences tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
?
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide Gallus gallus in uricotelic organisms such as birds, the major role of this active pathway is elimination of waste nitrogen tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
?
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide Gallus gallus essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
?
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide Mus musculus essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
?

Organism

Organism UniProt Comment Textmining
Gallus gallus
-
chicken
-
Mus musculus
-
mouse
-

Purification (Commentary)

Purification (Comment) Organism
-
Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
L-5178-Y cell murine lymphoma cell line Mus musculus
-
liver
-
Gallus gallus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.3
-
-
Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
10-formyl-5,8-dideazafolate + carbocyclic beta-glycinamide ribonucleotide
-
Mus musculus 5,8-dideazafolate + N-formyl carbocyclic beta-glycinamide ribonucleotide
-
?
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide
-
Gallus gallus tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
?
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide
-
Mus musculus tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
?
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide in ureotelic animals such as mammals the role of the far less active pathway is to provide purine nucleotides for further anabolic sequences Mus musculus tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
?
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide in uricotelic organisms such as birds, the major role of this active pathway is elimination of waste nitrogen Gallus gallus tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
?
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway Gallus gallus tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
?
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway Mus musculus tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
?
5'-phosphoribosylglycinamide + 10-formyl-5,8-dideazafolate
-
Gallus gallus 5'-phosphoribosyl-N-formylglycinamide + 5,8-dideazafolate
-
r

Subunits

Subunits Comment Organism
dimer 2 * 61000, SDS-PAGE Gallus gallus
monomer
-
Gallus gallus
monomer 1 * 110000, SDS-PAGE Mus musculus
monomer 1 * 102000, SDS-PAGE Mus musculus

Cofactor

Cofactor Comment Organism Structure
10-formyl-5,8-dideazafolate
-
Mus musculus