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Literature summary for 2.1.2.2 extracted from

  • Chen, P.; Schulze-Gahmen, U.; Stura, E.A.; Inglese, J.; Johnson, D.L.; Marolewski, A.; Benkovic, S.J.; Wilson, I.A.
    Crystal structure of glycinamide ribonucleotide transformylase from Escherichia coli at 3.0 A resolution (1992), J. Mol. Biol., 227, 283-292.
    View publication on PubMed

Application

Application Comment Organism
medicine pharmacological importance, target enzyme for chemotherapy, development of novel antifolate drugs, to be used as anti-cancer drugs Mus musculus
medicine pharmacological importance, target enzyme for chemotherapy, development of novel antifolate drugs, to be used as anti-cancer drugs Escherichia coli
medicine pharmacological importance, target enzyme for chemotherapy, development of novel antifolate drugs, to be used as anti-cancer drugs Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
-
Escherichia coli
cloned by functional complementation in Escherichia coli Homo sapiens
cloning of a 12-gene cluster encoding 9 enzymes for de novo purine nucleotide synthesis Bacillus subtilis

Crystallization (Commentary)

Crystallization (Comment) Organism
crystals grown by vapor diffusion, space group C222, a = 140.5 A, b = 98.2 A, c = 103.3 A Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
5,10-dideaza-5,6,7,8-tetrahydrofolate
-
Escherichia coli
5,10-dideaza-5,6,7,8-tetrahydrofolate
-
Homo sapiens
5,10-dideazatetrahydrofolate
-
Escherichia coli
5,10-dideazatetrahydrofolate
-
Homo sapiens
5,10-dideazatetrahydrofolate
-
Mus musculus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
23000
-
-
Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide Bacillus subtilis
-
tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
?
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide Saccharomyces cerevisiae
-
tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
?
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide Drosophila melanogaster essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
?
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide Mus musculus essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
?
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide Escherichia coli essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
?
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide Homo sapiens essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
?
10-formyltetrahydrofolate + glycinamide ribonucleotide Mus musculus
-
tetrahydrofolate + formylglycinamide ribonucleotide
-
?
10-formyltetrahydrofolate + glycinamide ribonucleotide Escherichia coli
-
tetrahydrofolate + formylglycinamide ribonucleotide
-
?

Organism

Organism UniProt Comment Textmining
Bacillus subtilis
-
-
-
Drosophila melanogaster
-
fruit fly
-
Escherichia coli
-
-
-
Homo sapiens
-
human
-
Mus musculus
-
mouse
-
Saccharomyces cerevisiae
-
yeast
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide
-
Drosophila melanogaster tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
?
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide
-
Bacillus subtilis tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
?
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide
-
Mus musculus tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
?
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide
-
Escherichia coli tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
?
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide
-
Homo sapiens tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
?
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide
-
Saccharomyces cerevisiae tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
?
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway Drosophila melanogaster tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
?
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway Mus musculus tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
?
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway Escherichia coli tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
?
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway Homo sapiens tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
?
10-formyltetrahydrofolate + glycinamide ribonucleotide
-
Mus musculus tetrahydrofolate + formylglycinamide ribonucleotide
-
?
10-formyltetrahydrofolate + glycinamide ribonucleotide
-
Escherichia coli tetrahydrofolate + formylglycinamide ribonucleotide
-
?
additional information monofunctional enzyme Bacillus subtilis ?
-
?
additional information monofunctional enzyme Escherichia coli ?
-
?
additional information 3 activities in a multifunctional protein, posessing glycinamide ribonucleotide synthetase, glycinamide ribonucleotidetransformylase and aminoimidazole ribonucleotide synthetase Mus musculus ?
-
?
additional information 3 activities in a multifunctional protein, posessing glycinamide ribonucleotide synthetase, glycinamide ribonucleotidetransformylase and aminoimidazole ribonucleotide synthetase Homo sapiens ?
-
?

Subunits

Subunits Comment Organism
dimer
-
Escherichia coli
dimer
-
Saccharomyces cerevisiae