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Literature summary for 2.1.2.2 extracted from

  • Smith, G.K.; Benkovic, P.A.; Benkovic, S.J.
    L(-)-10-formyltetrahydrofolate is the cofactor for glycinamide ribonucleotide transformylase from chicken liver (1981), Biochemistry, 20, 4034-4036.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
L-(+)-10-formyltetrahydrofolate excellent competitive inhibitor Gallus gallus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00576
-
L-(+)-5,10-methenyltetrahydrofolate
-
Gallus gallus
0.00594
-
L-(-)-10-formyltetrahydrofolate in absence of trifunctional protein Gallus gallus
0.00676
-
L-(-)-10-formyltetrahydrofolate
-
Gallus gallus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide Gallus gallus
-
tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Gallus gallus
-
chicken
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Gallus gallus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide
-
Gallus gallus tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
?
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide
-
Escherichia coli tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
?

Cofactor

Cofactor Comment Organism Structure
L-(+-)-5,10-methenyltetrahydrofolate
-
Gallus gallus
L-(-)-10-formyltetrahydrofolate
-
Gallus gallus
L-(-)-10-formyltetrahydrofolate
-
Escherichia coli