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Literature summary for 2.1.2.11 extracted from
- Elevated levels of ketopantoate hydroxymethyltransferase (PanB) lead to a physiologically significant coenzyme A elevation in Salmonella enterica serovar typhimurium (2002), J. Bacteriol., 184, 2827-2832.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| panB gene encoding enzyme is clustered together with other pantothenate biosynthetic genes panC and panD at 3 min of the chromosome map, panBCD operon | Salmonella enterica |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | panBp654 mutant with insertion of one GC base pair upstream of the transcription start site results in an optimized panBCD promoter and a 10fold increase in transcription of the pan operon, i.e. an increased expression of panB, which is sufficient to increase pantothenate biosynthesis | Salmonella enterica |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate | Salmonella enterica | biosynthesis of pantothenate | tetrahydrofolate + 2-dehydropantoate | - |
? |  |
| 5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate | Salmonella enterica | enzyme may be the rate-limiting reaction in pantothenate biosynthesis | tetrahydrofolate + 2-dehydropantoate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Salmonella enterica | - |
serovar typhimurium | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate | - |
Salmonella enterica | tetrahydrofolate + 2-dehydropantoate | - |
? | |
| 5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate | biosynthesis of pantothenate | Salmonella enterica | tetrahydrofolate + 2-dehydropantoate | - |
? | |
| 5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate | enzyme may be the rate-limiting reaction in pantothenate biosynthesis | Salmonella enterica | tetrahydrofolate + 2-dehydropantoate | - |
? | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| 5,10-methylenetetrahydrofolate | - |
Salmonella enterica | |
| tetrahydrofolate | - |
Salmonella enterica | |
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