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Literature summary for 2.1.2.1 extracted from
- Investigation of serine hydroxymethyltransferase in methanogens (1998), Can. J. Microbiol., 44, 652-656.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.065 | - |
tetrahydrofolate | pH and temperature not specified in the publication | Methanospirillum hungatei |  |
| 0.086 | - |
tetrahydrofolate | pH and temperature not specified in the publication | Methanosarcina barkeri | |
| 0.29 | - |
L-serine | pH and temperature not specified in the publication | Methanosarcina barkeri | |
| 0.31 | - |
L-serine | pH and temperature not specified in the publication | Methanospirillum hungatei | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Methanolobus tindarius | - |
- |
- |
| Methanosarcina barkeri | Q46A52 | - |
- |
| Methanosarcina barkeri DSM 804 | Q46A52 | - |
- |
| Methanospirillum hungatei | - |
- |
- |
| Methanospirillum hungatei GP1 | - |
- |
- |
| Methanothrix soehngenii | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| tetrahydrofolate + L-serine | - |
Methanothrix soehngenii | 5,10-methylenetetrahydrofolate + glycine + H2O | - |
? | |
| tetrahydrofolate + L-serine | - |
Methanospirillum hungatei | 5,10-methylenetetrahydrofolate + glycine + H2O | - |
? | |
| tetrahydrofolate + L-serine | - |
Methanolobus tindarius | 5,10-methylenetetrahydrofolate + glycine + H2O | - |
? | |
| tetrahydrofolate + L-serine | - |
Methanosarcina barkeri | 5,10-methylenetetrahydrofolate + glycine + H2O | - |
? | |
| tetrahydrofolate + L-serine | - |
Methanospirillum hungatei GP1 | 5,10-methylenetetrahydrofolate + glycine + H2O | - |
? | |
| tetrahydrofolate + L-serine | - |
Methanosarcina barkeri DSM 804 | 5,10-methylenetetrahydrofolate + glycine + H2O | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| SHMT | - |
Methanothrix soehngenii |
| SHMT | - |
Methanospirillum hungatei |
| SHMT | - |
Methanolobus tindarius |
| SHMT | - |
Methanosarcina barkeri |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| pyridoxal 5'-phosphate | stimulates activity | Methanospirillum hungatei | |
| pyridoxal 5'-phosphate | stimulates activity | Methanosarcina barkeri | |
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