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Literature summary for 2.1.2.1 extracted from

  • Engel, N.; Ewald, R.; Gupta, K.J.; Zrenner, R.; Hagemann, M.; Bauwe, H.
    The presequence of Arabidopsis serine hydroxymethyltransferase SHM2 selectively prevents import into mesophyll mitochondria (2011), Plant Physiol., 157, 1711-1720.
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
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Arabidopsis thaliana 5739
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Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana
-
-
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Source Tissue

Source Tissue Comment Organism Textmining
leaf mesophyll Arabidopsis thaliana
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additional information cellular distribution of SHM1 and SHM2, detailed overview Arabidopsis thaliana
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root dominance of the SHM2 over SHM1 transcripts in roots Arabidopsis thaliana
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vascular tissue protoxylem and/or adjacent cells, SHM1 and SHM2 Arabidopsis thaliana
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Synonyms

Synonyms Comment Organism
serine hydroxymethyltransferase
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Arabidopsis thaliana
SHM1
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Arabidopsis thaliana
SHM2
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Arabidopsis thaliana

General Information

General Information Comment Organism
malfunction a shm1 null mutant requires CO2-enriched air to inhibit photorespiration, while a shm2 null mutant does not show any visible impairment, a double-null mutant cannot survive in CO2-enriched air. Residual SHM activity is undetectably low in purified leaf mesophyll mitochondria of the shm1 mutant. In roots, the knockout of SHM1 does not reduce total SHM activity, whereas the knockout of SHM2 significantly lowers total SHM activity Arabidopsis thaliana
additional information kinetic properties of SHM2 might render this enzyme unsuitable for the high-folate conditions of photorespiring mesophyll mitochondria Arabidopsis thaliana
physiological function serine hydroxymethyltransferases are important enzymes of cellular one-carbon metabolism and are essential for the photorespiratory glycine-into-serine conversion in leaf mesophyll mitochondria. SHM1 is the photorespiratory isozyme. Due to exclusion of SHM2 from the photorespiratory environment of mesophyll mitochondria, SHM2 cannot substitute for SHM1 in photorespiratory metabolism. SHM1 and SHM2 operate in a redundant manner in one-carbon metabolism of nonphotorespiring cells with a high demand of one-carbon units, e.g. during lignification of vascular cells, detailed overview Arabidopsis thaliana