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Literature summary for 2.1.2.1 extracted from

  • MacFarlane, A.J.; Liu, X.; Perry, C.A.; Flodby, P.; Allen, R.H.; Stabler, S.P.; Stover, P.J.
    Cytoplasmic serine hydroxymethyltransferase regulates the metabolic partitioning of methylenetetrahydrofolate but is not essential in mice (2008), J. Biol. Chem., 283, 25846-25853.
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Mus musculus 5737
-

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
embryonic stem cell
-
Mus musculus
-
MEF cell
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-serine + tetrahydrofolate
-
Mus musculus glycine + 5,10-methylenetetrahydrofolate + H2O
-
r

Synonyms

Synonyms Comment Organism
serine hydroxymethyltransferase
-
Mus musculus
SHMT
-
Mus musculus

General Information

General Information Comment Organism
malfunction Shmt1 null mice are fertile and do not demonstrate maternal lethality Mus musculus
metabolism the enzyme regulates the partitioning of 5,10-methylenetetrahydrofolate between the thymidylate and homocysteine remethylation pathways, mitochondrial SHMT-derived one-carbon units are essential for folate-mediated one-carbon metabolism in the cytoplasm Mus musculus
physiological function cytoplasmic serine hydroxymethyltransferase regulates the metabolic partitioning of methylenetetrahydrofolate but is not essential in mice Mus musculus