Literature summary for 2.1.2.1 extracted from

Goyer, A.; Collakova, E.; Diaz de la Garza, R.; Quinlivan, E.P.; Williamson, J.; Gregory, J.F., 3rd; Shachar-Hill, Y.; Hanson, A.D.
5-Formyltetrahydrofolate is an inhibitory but well tolerated metabolite in Arabidopsis leaves (2005), J. Biol. Chem., 280, 26137-26142.

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Protein Variants

Protein Variants	Comment	Organism
additional information	5-CHO-THF cycloligase mutant, doubled leaf 5-formyltetrahydrofolate level, little impact on SHMT activity, but glycine content of mutant leaves is 19fold higher than the wild-type, also a small accumulation of serine in the mutant relative to the wild-type	Arabidopsis thaliana

Inhibitors

Inhibitors	Comment	Organism	Structure
5-formyltetrahydrofolate	can inhibit SHMT in vivo and thereby influence glycine pool size, can accumulate glycine in both wild-type and 5-CHO-THF cycloligase mutant	Arabidopsis thaliana

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	-	Arabidopsis thaliana	5739	-

Organism

Organism	UniProt	Comment	Textmining
Arabidopsis thaliana	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
leaf	-	Arabidopsis thaliana	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-serine + tetrahydrofolate	-	Arabidopsis thaliana	glycine + 5,10-methylenetetrahydrofolate + H2O	-	?

Synonyms

Synonyms	Comment	Organism
serine hydroxymethyltransferase	-	Arabidopsis thaliana
SHMT	-	Arabidopsis thaliana

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Release 2023.1 (January 2023)