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Literature summary for 2.1.1.9 extracted from
- Thiol S-methyltransferase (1981), Methods Enzymol., 77, 257-262.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| N-ethylmaleimide | - |
Rattus norvegicus |  |
| p-chloromercuribenzoate | - |
Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | - |
Rattus norvegicus | |
| 0.00054 | - |
4-Chlorothiophenol | - |
Rattus norvegicus | |
| 0.0011 | - |
phenyl sulfide | - |
Rattus norvegicus | |
| 0.0028 | - |
4-Nitrothiophenol | - |
Rattus norvegicus | |
| 0.012 | - |
Diethylthiocarbamoyl sulfide | - |
Rattus norvegicus | |
| 0.043 | - |
2-Thioacetanilide | - |
Rattus norvegicus | |
| 0.11 | - |
2-Benzimidazole thiol | - |
Rattus norvegicus | |
| 0.19 | - |
thioglycolic acid | - |
Rattus norvegicus | |
| 0.21 | - |
L-cysteine methyl ester | - |
Rattus norvegicus | |
| 0.4 | - |
N-acetyl-L-cysteine | - |
Rattus norvegicus | |
| 1 | - |
6-Propyl-2-thiouracil | - |
Rattus norvegicus | |
| 1.2 | - |
2-mercaptopropionic acid | - |
Rattus norvegicus | |
| 1.4 | - |
1-methylimidazol-2-thiol | - |
Rattus norvegicus | |
| 1.6 | - |
2,3-Dimercaptopropanol | - |
Rattus norvegicus | |
| 4.7 | - |
3-mercaptopropionic acid methyl ester | - |
Rattus norvegicus | |
| 8.1 | - |
2-mercaptoethanol | - |
Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Rattus norvegicus | - |
- |
| soluble | in extracts of liver, kidney, intestine and spleen | Rattus norvegicus | - |
- |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 28000 | - |
1 * 28000, SDS-PAGE | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Rattus norvegicus | role in detoxification of hydrogen sulfide that is generated by the colonic flora | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| intestine | - |
Rattus norvegicus | - |
| kidney | - |
Rattus norvegicus | - |
| liver | - |
Rattus norvegicus | - |
| spleen | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1-methylimidazole-2-thiol + S-adenosyl-L-methionine | - |
Rattus norvegicus | 1-methyl-2-(methylthio)-1H-imidazole + S-adenosyl-L-homocysteine | - |
? | |
| 2,3-dimercaptopropanol + S-adenosyl-L-methionine | - |
Rattus norvegicus | ? + S-adenosyl-L-homocysteine | - |
? | |
| 2-benzimidazole thiol + S-adenosyl-L-methionine | - |
Rattus norvegicus | ? + S-adenosyl-L-homocysteine | - |
? | |
| 2-mercaptopropionic acid + S-adenosyl-L-methionine | - |
Rattus norvegicus | S-methyl-2-mercaptopropionic acid + S-adenosyl-L-homocysteine | - |
? | |
| 2-thioacetanilide + S-adenosyl-L-methionine | - |
Rattus norvegicus | S-methyl-2-thioacetanilide + S-adenosyl-L-homocysteine | - |
? | |
| 3-mercaptopropionic acid methyl ester + S-adenosyl-L-methionine | - |
Rattus norvegicus | S-methyl-3-mercaptopropionic acid methyl ester + S-adenosyl-L-homocysteine | - |
? | |
| 4-chlorothiophenol + S-adenosyl-L-methionine | - |
Rattus norvegicus | 4-chloro-S-methylphenylmercaptan + S-adenosyl-L-homocysteine | - |
? | |
| 4-nitrothiophenol + S-adenosyl-L-methionine | - |
Rattus norvegicus | 4-nitro-S-methylphenylmercaptan + S-adenosyl-L-homocysteine | - |
? | |
| 6-propyl-2-thiouracil + S-adenosyl-L-methionine | - |
Rattus norvegicus | 6-propyl-S-methyl-2-thiouracil + S-adenosyl-L-homocysteine | - |
? | |
| diethylthiocarbamoyl sulfide + S-adenosyl-L-methionine | - |
Rattus norvegicus | ? + S-adenosyl-L-homocysteine | - |
? | |
| L-cysteine methyl ester + S-adenosyl-L-methionine | - |
Rattus norvegicus | S-methyl-L-cysteine methyl ester + S-adenosyl-L-homocysteine | - |
? | |
| mercaptoacetic acid + S-adenosyl-L-methionine | - |
Rattus norvegicus | S-methylmercaptoacetic acid + S-adenosyl-L-homocysteine | - |
? | |
| additional information | role in detoxification of hydrogen sulfide that is generated by the colonic flora | Rattus norvegicus | ? | - |
? | |
| N-acetyl-L-cysteine + S-adenosyl-L-methionine | - |
Rattus norvegicus | N-acetyl-S-methyl-L-cysteine + S-adenosyl-L-homocysteine | - |
? | |
| phenyl sulfide + S-adenosyl-L-methionine | - |
Rattus norvegicus | ? + S-adenosyl-L-homocysteine | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| monomer | 1 * 28000, SDS-PAGE | Rattus norvegicus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
- |
Rattus norvegicus |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 6.6 | 8.6 | about 50% of maximum activity at pH 6.6 and pH 8.6 | Rattus norvegicus |
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Release 2023.1 (January 2023)
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