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Literature summary for 2.1.1.87 extracted from

  • Damani, L.A.; Shaker, M.S.; Crooks, P.A.; Godin, C.S.; Nwosu, C.
    N-methylation and quaternization of pyridine in vitro by rabbit lung, liver and kidney N-methyltransferases: an S-adenosyl-L-methionine-dependent reaction (1986), Xenobiotica, 16, 645-650.
    View publication on PubMed
Search for more literature for 2.1.1.87

Inhibitors

Inhibitors Comment Organism Structure
additional information endogenous low-molecular-weight substance, enzyme activity increases after dialysis Oryctolagus cuniculus
S-adenosyl-L-homocysteine
-
 Oryctolagus cuniculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol no activity in mitochondria or microsomes Oryctolagus cuniculus 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + pyridine Oryctolagus cuniculus
-
 S-adenosyl-L-homocysteine + N-methylpyridinium
-
 ?

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
 rabbit, strain New Zealand White
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
 Oryctolagus cuniculus
-
liver
-
 Oryctolagus cuniculus
-
lung
-
 Oryctolagus cuniculus
-
additional information no activity in brain Oryctolagus cuniculus
-

Storage Stability

Storage Stability Organism
-20°C, up to a month Oryctolagus cuniculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + pyridine
-
 Oryctolagus cuniculus S-adenosyl-L-homocysteine + N-methylpyridinium
-
 ?
S-adenosyl-L-methionine + pyridine N5-methyltetrahydrofolic acid cannot replace S-adenosyl-L-methionine Oryctolagus cuniculus S-adenosyl-L-homocysteine + N-methylpyridinium
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Oryctolagus cuniculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.9
-
 assay at Oryctolagus cuniculus