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Literature summary for 2.1.1.79 extracted from

  • Oyola, S.O.; Evans, K.J.; Smith, T.K.; Smith, B.A.; Hilley, J.D.; Mottram, J.C.; Kaye, P.M.; Smith, D.F.
    Functional analysis of Leishmania cyclopropane fatty acid synthetase (2012), PLoS ONE, 7, e51300.
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum during the early log phase of extracellular growth, the enzyme shows partial localisation to the endoplasmic reticulum Leishmania infantum 5783
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
55000
-
x * 55000, calculated from amino acid sequence Leishmania infantum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + phospholipid olefinic fatty acid Leishmania infantum
-
S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid
-
?

Organism

Organism UniProt Comment Textmining
Leishmania infantum
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clone JPCM5 MCAN/ES/98/LLM-877
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Source Tissue

Source Tissue Comment Organism Textmining
promastigote
-
Leishmania infantum
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + phospholipid olefinic fatty acid
-
Leishmania infantum S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid
-
?

Subunits

Subunits Comment Organism
? x * 55000, calculated from amino acid sequence Leishmania infantum

Synonyms

Synonyms Comment Organism
CFAS
-
Leishmania infantum
cyclopropane fatty acid synthetase
-
Leishmania infantum

General Information

General Information Comment Organism
malfunction enzyme loss does not affect extracellular parasite growth, phagocytosis or early survival in macrophages, however, membrane transporter activity is defective and the null parasites are more resistant to oxidative stress Leishmania infantum