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Literature summary for 2.1.1.77 extracted from

  • Ouazia, D.; Levros, L.C.; Rassart, E.; Desrosiers, R.R.
    The protein L-isoaspartyl (D-aspartyl) methyltransferase protects against dopamine-induced apoptosis in neuroblastoma SH-SY5Y cells (2015), Neuroscience, 295, 139-150 .
    View publication on PubMed
Search for more literature for 2.1.1.77

Protein Variants

Protein Variants Comment Organism
D83V catalytically inactive Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + protein L-isoaspartate Homo sapiens
-
 S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
neuroblastoma cell
-
 Homo sapiens
-
SH-SY5Y cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + protein L-isoaspartate
-
 Homo sapiens S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester
-
 ?

Synonyms

Synonyms Comment Organism
PIMT
-
 Homo sapiens
protein L-isoaspartyl (D-aspartyl) methyltransferase
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens enzyme expression is down-regulated at both gene and protein levels by cytosolic dopamine in SH-SY5Y cells down

General Information

General Information Comment Organism
malfunction dopamine-associated enzyme downregulation leads to neuronal cell apoptosis Homo sapiens
physiological function enzyme overexpression protects SH-SY5Y cells from cell death and caspase 3 activation upon dopamine treatments. Cells overexpressing enzyme produce significantly less reactive oxygen species despite dopamine treatment Homo sapiens