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Literature summary for 2.1.1.77 extracted from
- The enzyme L-isoaspartyl (D-aspartyl) methyltransferase is required for VEGF-dependent endothelial cell migration and tubulogenesis (2016), Mol. Cell. Biochem., 413, 37-46 .
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| D83V | inactive | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-methionine + protein L-isoaspartate | Homo sapiens | - |
S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HUVEC cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-methionine + protein L-isoaspartate | - |
Homo sapiens | S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| L-isoaspartyl (D-aspartyl) methyltransferase | - |
Homo sapiens |
| PIMT | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | enzyme down-regulation in HUVEC cells inhibits both cell migration and tube formation in vitro when stimulated by vascular endothelial growth factor | Homo sapiens |
| physiological function | the enzyme is required for vascular endothelial growth factor-dependent endothelial cell migration and tubulogenesis. Enzyme overexpression promotes angiogenic properties in HUVEC cells | Homo sapiens |
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Release 2023.1 (January 2023)
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