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Literature summary for 2.1.1.77 extracted from

  • Yan, G.; Qin, Q.; Yi, B.; Chuprun, K.; Sun, H.; Huang, S.; Sun, J.
    Protein-L-isoaspartate (D-aspartate) O-methyltransferase protects cardiomyocytes against hypoxia induced apoptosis through inhibiting proapoptotic kinase Mst1 (2013), Int. J. Cardiol., 168, 3291-3299.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
CGP3466B
-
Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expressed in HEK-293 cells Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + protein D-aspartate Homo sapiens
-
S-adenosyl-L-homocysteine + protein D-aspartate methyl ester
-
?
S-adenosyl-L-methionine + protein L-isoaspartate Homo sapiens
-
S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cardiomyocyte
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + histone H2B L-isoaspartate
-
Homo sapiens S-adenosyl-L-homocysteine + histone H2B L-isoaspartate alpha-methyl ester
-
?
S-adenosyl-L-methionine + protein D-aspartate
-
Homo sapiens S-adenosyl-L-homocysteine + protein D-aspartate methyl ester
-
?
S-adenosyl-L-methionine + protein L-isoaspartate
-
Homo sapiens S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester
-
?

Synonyms

Synonyms Comment Organism
PCMT1
-
Homo sapiens
protein-L-isoaspartate (D-aspartate) O-methyltransferase
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens CGP3466B upregulates enzyme expression up

General Information

General Information Comment Organism
physiological function the enzyme is an inhibitor of hypoxia/reoxygenation-induced activation of mammalian sterile 20-like kinase 1 and cell apoptosis in cardiomyocytes Homo sapiens