Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Bos taurus | PIMT level is downregulated by proteasomal degradation, involving the PI3K pathway, during cell attachment. The regulation of PIMT level upon cell-substratum contact suggests a potential role for PIMT in biological processes such as wound healing, cell migration, and tumor metastasis dissemination | ? | - |
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Organism | UniProt | Comment | Textmining |
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Bos taurus | - |
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Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
aortic endothelium | PIMT expression in bovine aortic endothelial cells is regulated by cell detachment and readhesion to a substratum | Bos taurus | - |
carcinoma cell | PIMT levels are regulated by cell adhesion in various cancer cell lines. The upregulation of PIMT expression could be prevented by an anti-alphavbeta3 antibody (LM609) or by a cyclic RGD peptide (XJ735) specific to integrin alphavbeta3. PIMT expression returns to the basal level when cells are replated on a substratum after detachment, though downregulation of PIMT expression could be partly prevented by the PI3K inhibitors LY294002 and wortmannin, as well as by the proteasome inhibitors MG-132, lactacystin, and beta-lactone | Bos taurus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | PIMT level is downregulated by proteasomal degradation, involving the PI3K pathway, during cell attachment. The regulation of PIMT level upon cell-substratum contact suggests a potential role for PIMT in biological processes such as wound healing, cell migration, and tumor metastasis dissemination | Bos taurus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PIMT | - |
Bos taurus |