Application | Comment | Organism |
---|---|---|
medicine | aging research, accumulation of damaged proteins have detrimental effects over the human lifespan | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
southern blot analysis of PCR amplified genomic DNA, human chromosome contains a single gene encoding the enzyme, PCMT1, mapped to the q24-25 region of chromosome 6 | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Mus musculus | 5829 | - |
cytosol | - |
Homo sapiens | 5829 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + protein L-isoaspartate | Mus musculus | - |
S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester | - |
? | |
S-adenosyl-L-methionine + protein L-isoaspartate | Homo sapiens | involved in the repair of age-damaged proteins, aspartyl and asparginyl residues that are susceptible to deamidation, isomerization and racemization | S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
human | - |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood | - |
Homo sapiens | - |
brain | - |
Mus musculus | - |
brain | - |
Homo sapiens | - |
erythrocyte | - |
Mus musculus | - |
erythrocyte | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + protein L-isoaspartate | - |
Mus musculus | S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester | - |
? | |
S-adenosyl-L-methionine + protein L-isoaspartate | - |
Homo sapiens | S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester | - |
? | |
S-adenosyl-L-methionine + protein L-isoaspartate | involved in the repair of age-damaged proteins, aspartyl and asparginyl residues that are susceptible to deamidation, isomerization and racemization | Homo sapiens | S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PCMT1 | - |
Mus musculus |
PCMT1 | - |
Homo sapiens |
protein L-isoaspartate (D-aspartate) O-methyltransferase | - |
Homo sapiens |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | 50 | - |
Homo sapiens |