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Literature summary for 2.1.1.77 extracted from
- Identification of isoaspartyl-containing sequences in peptides and proteins that are usually poor substrates for the class II protein carboxyl methyltransferase (1990), J. Biol. Chem., 265, 3106-3110.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0004 | - |
KASA (isoD) LAKY | - |
Homo sapiens |  |
| 0.00055 | - |
KQVV-isoD-SAYEVIK | - |
Bos taurus | |
| 0.00088 | - |
KASA (isoD) LAKY | - |
Bos taurus | |
| 0.0012 | - |
synapsin I | - |
Bos taurus | |
| 0.00167 | - |
VYP-isoD-AA | - |
Bos taurus | |
| 0.0028 | - |
VYP-isoD-CA | - |
Homo sapiens | |
| 0.00295 | - |
VYP-isoD-DA | - |
Homo sapiens | |
| 0.00304 | - |
VYP-isoD-SA | - |
Bos taurus | |
| 0.0035 | - |
GFDL-isoD-GGGVG | - |
Bos taurus | |
| 0.0036 | - |
LSH-isoD-GYCL | - |
Homo sapiens | |
| 0.00425 | - |
VYP-isoD-GA | - |
Bos taurus | |
| 0.0046 | - |
YVS-isoD-GCG | - |
Homo sapiens | |
| 0.005 | - |
WM-isoD-F-NH2 | - |
Homo sapiens | |
| 0.00617 | - |
KVTCK-isoD-GQTNCYQSK | - |
Bos taurus | |
| 0.0062 | - |
VYP-isoD-GA | - |
Homo sapiens | |
| 0.017 | - |
LSH-isoD-GY-Cya-L | - |
Homo sapiens | |
| 0.0368 | - |
ovalbumin | - |
Bos taurus | |
| 0.104 | - |
YVS-isoD-G-Cya-G | - |
Homo sapiens | |
| 0.175 | - |
VYP-isoD-Cya-G | - |
Homo sapiens | |
| 0.183 | - |
beta-101-lysozyme | - |
Homo sapiens | |
| 0.469 | - |
YVS-isoD-GDG | - |
Homo sapiens | |
| 1.081 | - |
native lysozyme | - |
Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-methionine + protein L-isoaspartate | Homo sapiens | - |
S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester | - |
? | |
| S-adenosyl-L-methionine + protein L-isoaspartate | Bos taurus | - |
S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
bovine | - |
| Homo sapiens | - |
human | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Homo sapiens | - |
| brain | - |
Bos taurus | - |
| erythrocyte | - |
Homo sapiens | - |
| erythrocyte | - |
Bos taurus | - |
| lens | - |
Bos taurus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-methionine + beta-101-lysozyme | - |
Homo sapiens | S-adenosyl-L-homocysteine + ? | - |
? | |
| S-adenosyl-L-methionine + GFDL-isoD-GGGVG | - |
Homo sapiens | S-adenosyl-L-homocysteine + ? | - |
? | |
| S-adenosyl-L-methionine + GFDL-isoD-GGGVG | - |
Bos taurus | S-adenosyl-L-homocysteine + ? | - |
? | |
| S-adenosyl-L-methionine + KASA (isoD) LAKY | - |
Homo sapiens | S-adenosyl-L-homocysteine + ? | - |
? | |
| S-adenosyl-L-methionine + KASA (isoD) LAKY | - |
Bos taurus | S-adenosyl-L-homocysteine + ? | - |
? | |
| S-adenosyl-L-methionine + KQVV-isoD-SAYEVIK | - |
Homo sapiens | S-adenosyl-L-homocysteine + ? | - |
? | |
| S-adenosyl-L-methionine + KQVV-isoD-SAYEVIK | - |
Bos taurus | S-adenosyl-L-homocysteine + ? | - |
? | |
| S-adenosyl-L-methionine + KVTCK-isoD-GQTNCYQSK | - |
Bos taurus | ? | - |
? | |
| S-adenosyl-L-methionine + LSH-isoD-GY-Cya-L | - |
Homo sapiens | S-adenosyl-L-homocysteine + ? | - |
? | |
| S-adenosyl-L-methionine + LSH-isoD-GYCL | - |
Homo sapiens | S-adenosyl-L-homocysteine + ? | - |
? | |
| S-adenosyl-L-methionine + native lysozyme | - |
Homo sapiens | S-adenosyl-L-homocysteine + ? | - |
? | |
| S-adenosyl-L-methionine + ovalbumin | - |
Homo sapiens | S-adenosyl-L-homocysteine + ? | - |
? | |
| S-adenosyl-L-methionine + ovalbumin | - |
Bos taurus | S-adenosyl-L-homocysteine + ? | - |
? | |
| S-adenosyl-L-methionine + protein D-aspartate | - |
Homo sapiens | S-adenosyl-L-homocysteine + protein D-aspartate beta-methyl ester | - |
? | |
| S-adenosyl-L-methionine + protein D-aspartate | - |
Bos taurus | S-adenosyl-L-homocysteine + protein D-aspartate beta-methyl ester | - |
? | |
| S-adenosyl-L-methionine + protein L-isoaspartate | - |
Homo sapiens | S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester | - |
? | |
| S-adenosyl-L-methionine + protein L-isoaspartate | - |
Bos taurus | S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester | - |
? | |
| S-adenosyl-L-methionine + synapsin I | - |
Homo sapiens | S-adenosyl-L-homocysteine + ? | - |
? | |
| S-adenosyl-L-methionine + synapsin I | - |
Bos taurus | S-adenosyl-L-homocysteine + ? | - |
? | |
| S-adenosyl-L-methionine + VYP-isoD-AA | - |
Bos taurus | ? | - |
? | |
| S-adenosyl-L-methionine + VYP-isoD-CA | - |
Homo sapiens | S-adenosyl-L-homocysteine + ? | - |
? | |
| S-adenosyl-L-methionine + VYP-isoD-Cya-G | - |
Homo sapiens | S-adenosyl-L-homocysteine + ? | - |
? | |
| S-adenosyl-L-methionine + VYP-isoD-DA | - |
Homo sapiens | S-adenosyl-L-homocysteine + ? | - |
? | |
| S-adenosyl-L-methionine + VYP-isoD-GA | - |
Homo sapiens | S-adenosyl-L-homocysteine + ? | - |
? | |
| S-adenosyl-L-methionine + VYP-isoD-GA | - |
Bos taurus | S-adenosyl-L-homocysteine + ? | - |
? | |
| S-adenosyl-L-methionine + VYP-isoD-SA | - |
Bos taurus | ? | - |
? | |
| S-adenosyl-L-methionine + WM-isoD-F-NH2 | - |
Homo sapiens | ? | - |
? | |
| S-adenosyl-L-methionine + YVS-isoD-G-Cya-G | - |
Homo sapiens | S-adenosyl-L-homocysteine + ? | - |
? | |
| S-adenosyl-L-methionine + YVS-isoD-GCG | - |
Homo sapiens | S-adenosyl-L-homocysteine + ? | - |
? | |
| S-adenosyl-L-methionine + YVS-isoD-GDG | - |
Homo sapiens | S-adenosyl-L-homocysteine + ? | - |
? | |
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