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Literature summary for 2.1.1.72 extracted from

  • Low, D.; Casadesus, J.
    Clocks and switches: bacterial gene regulation by DNA adenine methylation (2008), Curr. Opin. Microbiol., 11, 106-112.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + DNA adenine Escherichia coli the target sequence is 5'GATC3' S-adenosyl-L-homocysteine + DNA 6-methyladenine
-
?
S-adenosyl-L-methionine + DNA adenine Yersinia pseudotuberculosis the target sequence is 5'GATC3' S-adenosyl-L-homocysteine + DNA 6-methyladenine
-
?
S-adenosyl-L-methionine + DNA adenine Salmonella enterica the target sequence is 5'GATC3' S-adenosyl-L-homocysteine + DNA 6-methyladenine
-
?
S-adenosyl-L-methionine + DNA adenine Caulobacter vibrioides the target sequence is 5'GATC3' S-adenosyl-L-homocysteine + DNA 6-methyladenine
-
?

Organism

Organism UniProt Comment Textmining
Caulobacter vibrioides
-
-
-
Escherichia coli
-
-
-
Salmonella enterica
-
-
-
Yersinia pseudotuberculosis
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + DNA adenine the target sequence is 5'GATC3' Escherichia coli S-adenosyl-L-homocysteine + DNA 6-methyladenine
-
?
S-adenosyl-L-methionine + DNA adenine the target sequence is 5'GATC3' Yersinia pseudotuberculosis S-adenosyl-L-homocysteine + DNA 6-methyladenine
-
?
S-adenosyl-L-methionine + DNA adenine the target sequence is 5'GATC3' Salmonella enterica S-adenosyl-L-homocysteine + DNA 6-methyladenine
-
?
S-adenosyl-L-methionine + DNA adenine the target sequence is 5'GATC3' Caulobacter vibrioides S-adenosyl-L-homocysteine + DNA 6-methyladenine
-
?

Synonyms

Synonyms Comment Organism
Dam
-
Escherichia coli
Dam
-
Yersinia pseudotuberculosis
Dam
-
Salmonella enterica
Dam
-
Caulobacter vibrioides
Dam methylase
-
Escherichia coli
Dam methylase
-
Yersinia pseudotuberculosis
Dam methylase
-
Salmonella enterica
Dam methylase
-
Caulobacter vibrioides
DNA adenine methyltransferase
-
Escherichia coli
DNA adenine methyltransferase
-
Yersinia pseudotuberculosis
DNA adenine methyltransferase
-
Salmonella enterica
DNA adenine methyltransferase
-
Caulobacter vibrioides

General Information

General Information Comment Organism
physiological function Dam methylation of finP prevents repression by H-NS,methlation of traJ leads to activation of Lrp binding to the traJ UAS by strand-specific hemimethylation Salmonella enterica
physiological function synthesis of P pili (pyelonephritis-associated protein) is subjected to phase variation and switching between On and Off states is controlled by Dam methylation, Dam methylation inhibits OxyR binding in the On state, Dam methylation of the upstream GATC site in agn43 increases transcription initiation, which occurs precisely at the G nucleotide of the GATC, finP transcription is activated by Dam methylation, Dam methylation does not regulate tir gene transcription nor tir mRNA stability Escherichia coli
physiological function transcriptional inhibition by hemimethylation of genes dnaA, ccrM, and ctrA Caulobacter vibrioides