Literature summary for 2.1.1.72 extracted from

Robbins-Manke, J.L.; Zdraveski, Z.Z.; Marinus, M.; Essigmann, J.M.
Analysis of global gene expression and double-strand-break formation in DNA adenine methyltransferase- and mismatch repair-deficient Escherichia coli (2005), J. Bacteriol., 187, 7027-7037.

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Application

Application	Comment	Organism
medicine	upregulation of recombinational repair in dam mutants allows for the efficient repair of double-strand breaks whose formation is dependent on functional mismatch repair	Escherichia coli

Protein Variants

Protein Variants	Comment	Organism
additional information	mutant strains dam, dam mutS, and mutS, deficient in dam and/or mismatch repair, mutS strain does not display many differences from the wild-type at the transcriptional level, both dam and dam mutS strains show differential expression of 206 and 114 genes and expression at higher levels as wild-type, dam mutS strain shows higher variability among some of these induced genes than the dam strain, dam strain has a significantly higher level of basal double-strand breaks than the dam mutS strain	Escherichia coli

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	derivatives of strain AB1157	-

Synonyms

Synonyms	Comment	Organism
Dam	-	Escherichia coli
DNA adenine methyltransferase	-	Escherichia coli

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Release 2023.1 (January 2023)