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Literature summary for 2.1.1.72 extracted from
- Structure, function and mechanism of exocyclic DNA methyltransferases (2006), Biochem. J., 399, 177-190.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | potential targets for both vaccines and antimicrobials | Escherichia coli |
| medicine | potential targets for both vaccines and antimicrobials | Enterobacter cloacae |
| medicine | potential targets for both vaccines and antimicrobials | Klebsiella pneumoniae |
| medicine | potential targets for both vaccines and antimicrobials | Caulobacter vibrioides |
| medicine | potential targets for both vaccines and antimicrobials | Tequatrovirus T4 |
| medicine | potential targets for both vaccines and antimicrobials | Thermus aquaticus |
| medicine | potential targets for both vaccines and antimicrobials | Streptococcus pneumoniae |
| medicine | potential targets for both vaccines and antimicrobials | Cereibacter sphaeroides |
| medicine | potential targets for both vaccines and antimicrobials | Moraxella bovis |
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
- |
Escherichia coli |
- |
Tequatrovirus T4 |
- |
Streptococcus pneumoniae |
- |
Cereibacter sphaeroides |
- |
Moraxella bovis |
| in complex with S-adenosyl-L-methionine, S-adenosyl-L-homocysteine and with the inhibitor sinefungin, at a resolution of 2.4 A | Thermus aquaticus |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | site-directed mutagenesis at the dimer interface drastically affects enzyme activity in addition to the oligomeric status of the enzyme | Klebsiella pneumoniae |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| sinefungin | competetive inhibitor | Thermus aquaticus |  |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0000036 | - |
DNA adenine | - |
Escherichia coli | |
| 0.0000174 | - |
DNA adenine | - |
Escherichia coli | |
| 0.0000255 | - |
DNA adenine | - |
Escherichia coli | |
| 0.00009 | - |
DNA adenine | - |
Klebsiella pneumoniae | |
| 0.00009 | - |
DNA adenine | - |
Streptococcus pneumoniae | |
| 0.00009 | - |
DNA adenine | - |
Moraxella bovis | |
| 0.000091 | - |
DNA adenine | - |
Enterobacter cloacae | |
| 0.000122 | - |
DNA adenine | - |
Escherichia coli | |
| 0.00015 | - |
DNA adenine | - |
Klebsiella pneumoniae | |
| 0.00015 | - |
DNA adenine | - |
Streptococcus pneumoniae | |
| 0.00015 | - |
DNA adenine | - |
Moraxella bovis | |
| 0.000182 | - |
DNA adenine | - |
Enterobacter cloacae | |
| 0.00027 | - |
DNA adenine | - |
Escherichia coli | |
| 0.0003 | - |
DNA adenine | - |
Escherichia coli | |
| 0.0006 | - |
DNA adenine | - |
Thermus aquaticus | |
| 0.0008 | - |
DNA adenine | - |
Escherichia coli | |
| 0.00083 | - |
DNA adenine | - |
Escherichia coli | |
| 0.00091 | - |
DNA adenine | - |
Escherichia coli | |
| 0.001 | - |
DNA adenine | - |
Escherichia coli | |
| 0.0018 | - |
S-adenosyl-L-methionine | - |
Enterobacter cloacae | |
| 0.00195 | - |
DNA adenine | - |
Klebsiella pneumoniae | |
| 0.00195 | - |
DNA adenine | - |
Streptococcus pneumoniae | |
| 0.00195 | - |
DNA adenine | - |
Moraxella bovis | |
| 0.0037 | - |
S-adenosyl-L-methionine | - |
Thermus aquaticus | |
| 0.0056 | - |
S-adenosyl-L-methionine | - |
Escherichia coli | |
| 0.0071 | - |
DNA adenine | - |
Escherichia coli | |
| 0.0122 | - |
S-adenosyl-L-methionine | - |
Escherichia coli | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Caulobacter vibrioides | - |
- |
- |
| Cereibacter sphaeroides | P14751 | - |
- |
| Enterobacter cloacae | - |
- |
- |
| Escherichia coli | - |
- |
- |
| Klebsiella pneumoniae | - |
- |
- |
| Moraxella bovis | P23192 | - |
- |
| Streptococcus pneumoniae | P04043 | - |
- |
| Tequatrovirus T4 | P04392 | - |
- |
| Thermus aquaticus | P14385 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-methionine + DNA adenine | - |
Escherichia coli | S-adenosyl-L-homocysteine + DNA 6-methyladenine | - |
? | |
| S-adenosyl-L-methionine + DNA adenine | - |
Enterobacter cloacae | S-adenosyl-L-homocysteine + DNA 6-methyladenine | - |
? | |
| S-adenosyl-L-methionine + DNA adenine | - |
Klebsiella pneumoniae | S-adenosyl-L-homocysteine + DNA 6-methyladenine | - |
? | |
| S-adenosyl-L-methionine + DNA adenine | - |
Caulobacter vibrioides | S-adenosyl-L-homocysteine + DNA 6-methyladenine | - |
? | |
| S-adenosyl-L-methionine + DNA adenine | - |
Tequatrovirus T4 | S-adenosyl-L-homocysteine + DNA 6-methyladenine | - |
? | |
| S-adenosyl-L-methionine + DNA adenine | - |
Thermus aquaticus | S-adenosyl-L-homocysteine + DNA 6-methyladenine | - |
? | |
| S-adenosyl-L-methionine + DNA adenine | - |
Streptococcus pneumoniae | S-adenosyl-L-homocysteine + DNA 6-methyladenine | - |
? | |
| S-adenosyl-L-methionine + DNA adenine | - |
Cereibacter sphaeroides | S-adenosyl-L-homocysteine + DNA 6-methyladenine | - |
? | |
| S-adenosyl-L-methionine + DNA adenine | - |
Moraxella bovis | S-adenosyl-L-homocysteine + DNA 6-methyladenine | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | - |
Escherichia coli |
| dimer | - |
Klebsiella pneumoniae |
| dimer | - |
Tequatrovirus T4 |
| dimer | - |
Moraxella bovis |
| dimer | dimerizes at high protein concentrations | Cereibacter sphaeroides |
| dimer | in solution, but dissociate into monomers upon addition of the DNA | Caulobacter vibrioides |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CcrM | - |
Caulobacter vibrioides |
| Dam | - |
Escherichia coli |
| Dam | - |
Enterobacter cloacae |
| Dam | - |
Klebsiella pneumoniae |
| Dam | - |
Caulobacter vibrioides |
| Dam | - |
Tequatrovirus T4 |
| Dam | - |
Thermus aquaticus |
| Dam | - |
Streptococcus pneumoniae |
| Dam | - |
Cereibacter sphaeroides |
| Dam | - |
Moraxella bovis |
| DNA adenine MTase | - |
Escherichia coli |
| DNA adenine MTase | - |
Enterobacter cloacae |
| DNA adenine MTase | - |
Klebsiella pneumoniae |
| DNA adenine MTase | - |
Caulobacter vibrioides |
| DNA adenine MTase | - |
Tequatrovirus T4 |
| DNA adenine MTase | - |
Thermus aquaticus |
| DNA adenine MTase | - |
Streptococcus pneumoniae |
| DNA adenine MTase | - |
Cereibacter sphaeroides |
| DNA adenine MTase | - |
Moraxella bovis |
| EcoDam | - |
Escherichia coli |
| M.DpnM | - |
Streptococcus pneumoniae |
| M.EcaI | - |
Enterobacter cloacae |
| M.EcoP15I | - |
Escherichia coli |
| M.EcoRI | - |
Escherichia coli |
| M.EcoRV | - |
Escherichia coli |
| M.KpnI | - |
Klebsiella pneumoniae |
| M.MboIIA | - |
Moraxella bovis |
| M.RsrI | - |
Cereibacter sphaeroides |
| M.TaqI | - |
Thermus aquaticus |
| N6-adenine MTase | - |
Escherichia coli |
| N6-adenine MTase | - |
Enterobacter cloacae |
| N6-adenine MTase | - |
Klebsiella pneumoniae |
| N6-adenine MTase | - |
Caulobacter vibrioides |
| N6-adenine MTase | - |
Tequatrovirus T4 |
| N6-adenine MTase | - |
Thermus aquaticus |
| N6-adenine MTase | - |
Streptococcus pneumoniae |
| N6-adenine MTase | - |
Cereibacter sphaeroides |
| N6-adenine MTase | - |
Moraxella bovis |
| T4 Dam | - |
Tequatrovirus T4 |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.000096 | - |
DNA adenine | - |
Escherichia coli | |
| 0.000118 | - |
S-adenosyl-L-methionine | - |
Escherichia coli | |
| 0.00021 | - |
S-adenosyl-L-methionine | - |
Escherichia coli | |
| 0.000248 | - |
S-adenosyl-L-methionine | - |
Escherichia coli | |
| 0.00028 | - |
S-adenosyl-L-methionine | - |
Escherichia coli | |
| 0.00033 | - |
DNA adenine | - |
Klebsiella pneumoniae | |
| 0.00033 | - |
DNA adenine | - |
Streptococcus pneumoniae | |
| 0.00033 | - |
DNA adenine | - |
Moraxella bovis | |
| 0.00072 | - |
DNA adenine | - |
Klebsiella pneumoniae | |
| 0.00072 | - |
DNA adenine | - |
Streptococcus pneumoniae | |
| 0.00072 | - |
DNA adenine | - |
Moraxella bovis | |
| 0.00117 | - |
S-adenosyl-L-methionine | - |
Escherichia coli | |
| 0.0022 | - |
DNA adenine | - |
Klebsiella pneumoniae | |
| 0.0022 | - |
DNA adenine | - |
Streptococcus pneumoniae | |
| 0.0022 | - |
DNA adenine | - |
Moraxella bovis | |
| 0.0025 | - |
DNA adenine | - |
Enterobacter cloacae | |
| 0.0041 | - |
DNA adenine | - |
Escherichia coli | |
| 0.0047 | - |
DNA adenine | - |
Enterobacter cloacae | |
| 0.0053 | - |
DNA adenine | - |
Escherichia coli | |
| 0.0056 | - |
DNA adenine | - |
Escherichia coli | |
| 0.0056 | - |
DNA adenine | - |
Klebsiella pneumoniae | |
| 0.0056 | - |
DNA adenine | - |
Streptococcus pneumoniae | |
| 0.0056 | - |
DNA adenine | - |
Moraxella bovis | |
| 0.019 | - |
DNA adenine | - |
Cereibacter sphaeroides | |
| 0.0208 | - |
DNA adenine | - |
Escherichia coli | |
| 0.094 | - |
DNA adenine | - |
Escherichia coli | |
| 0.105 | - |
DNA adenine | - |
Escherichia coli | |
| 0.11 | - |
DNA adenine | - |
Escherichia coli | |
| 0.124 | - |
DNA adenine | - |
Escherichia coli | |
| 0.14 | - |
DNA adenine | - |
Escherichia coli | |
| 0.142 | - |
DNA adenine | - |
Escherichia coli | |
| 0.16 | - |
DNA adenine | - |
Escherichia coli | |
| 0.167 | - |
DNA adenine | - |
Escherichia coli | |
| 0.203 | - |
DNA adenine | - |
Escherichia coli | |
| 0.23 | - |
DNA adenine | - |
Escherichia coli | |
| 0.25 | - |
DNA adenine | - |
Escherichia coli | |
| 0.27 | - |
DNA adenine | - |
Escherichia coli | |
| 0.3 | - |
DNA adenine | - |
Escherichia coli | |
| 0.316 | - |
DNA adenine | - |
Escherichia coli | |
| 0.33 | - |
DNA adenine | - |
Caulobacter vibrioides | |
| 0.37 | - |
DNA adenine | - |
Escherichia coli | |
| 0.447 | - |
DNA adenine | - |
Escherichia coli | |
| 0.58 | - |
DNA adenine | - |
Escherichia coli | |
| 0.73 | - |
DNA adenine | - |
Thermus aquaticus | |
| 0.93 | - |
DNA adenine | - |
Escherichia coli | |
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