Literature summary for 2.1.1.72 extracted from

Baskunov, V.B.; Subach, F.V.; Kolbanovskiy, A.; Kolbanovskiy, M.; Eremin, S.A.; Johnson, F.; Bonala, R.; Geacintov, N.E.; Gromova, E.S.
Effects of benzo[a]pyrene-deoxyguanosine lesions on DNA methylation catalyzed by EcoRII DNA methyltransferase and on DNA cleavage effected by EcoRII restriction endonuclease (2005), Biochemistry, 44, 1054-1066.

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Application

Application	Comment	Organism
medicine	epigenetic effects, in addition to genotoxic effects, need to be considered in chemical carcinogenesis initiated by r7,t8-dihydroxy-t9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene, since the inhibition of methylation may allow the expression of genes that promote tumor development	Escherichia coli

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	catalyzes the transfer of a methyl group to the C5 position of the 3'-side cytosine of each strand of the recognition sequence, M.EcoRII binding is diminished by factors of 5-30 but the catalytic activity is either abolished or reduced 4-80fold when trans-anti-B[a]P-N2-dG lesions are introduced into the EcoRII recognition sequence, methylation rates are also diminished and in some cases entirely abolished, depending on the position of the lesion within the recognition sequence	Escherichia coli	?	-	?

Synonyms

Synonyms	Comment	Organism
EcoRII DNA methyltransferase	-	Escherichia coli
M.EcoRII	-	Escherichia coli

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Release 2023.1 (January 2023)