Literature summary for 2.1.1.72 extracted from

Zinoviev, V.V.; Yakishchik, S.I.; Evdokimov, A.A.; Malygin, E.G.; Hattman, S.
Symmetry elements in DNA structure important for recognition/methylation by DNA [amino]-methyltransferases (2004), Nucleic Acids Res., 32, 3930-3934.

Search for more literature for 2.1.1.72

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
additional information	-	additional information	detailed kinetics for diverse substrate duplexes and methylation sites	Escherichia coli
additional information	-	additional information	detailed kinetics for diverse substrate duplexes and methylation sites	Tequatrovirus T4

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
S-adenosyl-L-methionine + DNA adenine	Escherichia coli	-	S-adenosyl-L-homocysteine + DNA 6-methylaminopurine	-	?
S-adenosyl-L-methionine + DNA adenine	Tequatrovirus T4	-	S-adenosyl-L-homocysteine + DNA 6-methylaminopurine	-	?

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	-	-
Tequatrovirus T4	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
S-adenosyl-L-methionine + DNA adenine	-	Escherichia coli	S-adenosyl-L-homocysteine + DNA 6-methylaminopurine	-	?
S-adenosyl-L-methionine + DNA adenine	-	Tequatrovirus T4	S-adenosyl-L-homocysteine + DNA 6-methylaminopurine	-	?
S-adenosyl-L-methionine + DNA adenine	specific for methylation site sequence GATC and structure, an intact GA sequence is essential for activity, altered structural symmetry of the DNA substrate decreases kcat sharply, the best contact between enzyme and DNA is a palindromic interaction site covering the 5'-symmetric residues, which is located in the major groove, and another one in the 3'-half covering the 3'-symmetric residues is located in the minor groove, overview	Escherichia coli	S-adenosyl-L-homocysteine + DNA 6-methylaminopurine	-	?
S-adenosyl-L-methionine + DNA adenine	specific for methylation site sequence GATC and structure, an intact GAT sequence is essential for activity, altered structural symmetry of the DNA substrate decreases kcat sharply, the best contact between enzyme and DNA is a palindromic interaction site covering the 5'-symmetric residues, which is located in the major groove, and another one in the 3'-half covering the 3'-symmetric residues is located in the minor groove, overview	Tequatrovirus T4	S-adenosyl-L-homocysteine + DNA 6-methylaminopurine	-	?

Synonyms

Synonyms	Comment	Organism
DNA [amino]-methyltransferase	-	Escherichia coli
DNA [amino]-methyltransferase	-	Tequatrovirus T4
DNA-[N6-adenine] MTase	-	Escherichia coli
DNA-[N6-adenine] MTase	-	Tequatrovirus T4
EcoDam	-	Escherichia coli
EcoDam DNA-[N6-adenine] MTase	-	Escherichia coli
T4Dam	-	Tequatrovirus T4
T4Dam DNA-[N6-adenine] MTase	-	Tequatrovirus T4
[N6-adenine] MTase	-	Escherichia coli
[N6-adenine] MTase	-	Tequatrovirus T4

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
25	-	assay at	Escherichia coli
25	-	assay at	Tequatrovirus T4

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
8	-	assay at	Escherichia coli
8	-	assay at	Tequatrovirus T4

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Release 2023.1 (January 2023)