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Literature summary for 2.1.1.72 extracted from

  • Zinoviev, V.V.; Evdokimov, A.A.; Malygin, E.G.; Schlagman, S.L.; Hattman, S.
    Bacteriophage T4 Dam DNA-(N6-adenine)-methyltransferase. Processivity and orientation to the methylation target (2003), J. Biol. Chem., 278, 7829-7833.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
fully methylated sites 5'-GMTC/5'-GMTC DNA the inhibition potential of fully methylated sites 5'-GMTC/5'-GMTC is much lower for a long DNA molecule compared to short single-site duplxes, enzyme does not dissociate from the DNA but continues one-sited methylation with linear diffusion, after which it rapidly reorientates itself and reconstitutes Tequatrovirus T4

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information detailed steady-state and pre-steady-state kinetics for different methylation sites Tequatrovirus T4

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Tequatrovirus T4 S-adenosyl-L-methionine plays a crucial role in reorientation of the enzyme in DNA with mutationally altered Ade residues to 2-aminopurine, overview ?
-
?
S-adenosyl-L-methionine + DNA adenine Tequatrovirus T4
-
S-adenosyl-L-homocysteine + DNA 6-methylaminopurine
-
?

Organism

Organism UniProt Comment Textmining
Tequatrovirus T4
-
-
-

Reaction

Reaction Comment Organism Reaction ID
S-adenosyl-L-methionine + adenine in DNA = S-adenosyl-L-homocysteine + N6-methyladenine in DNA ordered bi bi mechanism during progressive methylation process Tequatrovirus T4

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information S-adenosyl-L-methionine plays a crucial role in reorientation of the enzyme in DNA with mutationally altered Ade residues to 2-aminopurine, overview Tequatrovirus T4 ?
-
?
S-adenosyl-L-methionine + DNA adenine
-
Tequatrovirus T4 S-adenosyl-L-homocysteine + DNA 6-methylaminopurine
-
?
S-adenosyl-L-methionine + DNA adenine specific methylation of oligonucleotide duplexes containing one or two target sequence GATC sites Tequatrovirus T4 S-adenosyl-L-homocysteine + DNA 6-methylaminopurine
-
?

Synonyms

Synonyms Comment Organism
DNA-(N6-adenine)-methyltransferase
-
Tequatrovirus T4
N6-Ade MTase
-
Tequatrovirus T4
T4 Dam
-
Tequatrovirus T4
T4 Dam DNA-(N6-adenine)-methyltransferase
-
Tequatrovirus T4
T4 Dam MTase
-
Tequatrovirus T4

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
assay at Tequatrovirus T4

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
additional information
-
additional information
-
Tequatrovirus T4
0.015
-
DNA adenine 20mer duplex, unligated, single-site, pH 8.0, 25°C Tequatrovirus T4

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
assay at Tequatrovirus T4