Protein Variants | Comment | Organism |
---|---|---|
A179G/G460A | the variant is associated with low enzyme activity | Homo sapiens |
A719G | the variant is associated with low enzyme activity | Homo sapiens |
G238C | the variant is associated with low enzyme activity | Homo sapiens |
G460A | the variant is associated with low enzyme activity | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P51580 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
erythrocyte | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + 6-mercaptopurine | - |
Homo sapiens | S-adenosyl-L-homocysteine + 6-methylmercaptopurine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
thiopurine methyltransferase | - |
Homo sapiens |
TPMT | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | intermediate and low enzyme activity may lead to leukopenia following thiopurine treatment | Homo sapiens |