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Literature summary for 2.1.1.67 extracted from

  • Hosni-Ahmed, A.; Barnes, J.D.; Wan, J.; Jones, T.S.
    Thiopurine methyltransferase predicts the extent of cytotoxicty and DNA damage in astroglial cells after thioguanine exposure (2011), PLoS ONE, 6, e29163.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine low enzyme level can lead to greater sensitivity to thiopurine therapy in astroglial cells Mus musculus
medicine low enzyme level can lead to greater sensitivity to thiopurine therapy in astroglial cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Mus musculus 5737
-
cytoplasm
-
Homo sapiens 5737
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-172 cell
-
Homo sapiens
-
astrocyte primary cell Mus musculus
-
astroglial cell
-
Mus musculus
-
T-98 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + 6-mercaptopurine
-
Mus musculus S-adenosyl-L-homocysteine + 6-methylmercaptopurine
-
?
S-adenosyl-L-methionine + 6-mercaptopurine
-
Homo sapiens S-adenosyl-L-homocysteine + 6-methylmercaptopurine
-
?
S-adenosyl-L-methionine + thioguanine nucleotide
-
Mus musculus S-adenosyl-L-homocysteine + methylthioguanine
-
?
S-adenosyl-L-methionine + thioguanine nucleotide
-
Homo sapiens S-adenosyl-L-homocysteine + methylthioguanine
-
?
S-adenosyl-L-methionine + thioinosine monophosphate
-
Mus musculus S-adenosyl-L-homocysteine + methylthioinosine monophosphate
-
?
S-adenosyl-L-methionine + thioinosine monophosphate
-
Homo sapiens S-adenosyl-L-homocysteine + methylthioinosine monophosphate
-
?

Synonyms

Synonyms Comment Organism
thiopurine methyltransferase
-
Mus musculus
thiopurine methyltransferase
-
Homo sapiens
TPMT
-
Mus musculus
TPMT
-
Homo sapiens

General Information

General Information Comment Organism
malfunction when thiopurine methyltransferase protein activity is low a greater degree of cytotoxicity and DNA damage can occur after thioguanine exposure Mus musculus
malfunction when thiopurine methyltransferase protein activity is low a greater degree of cytotoxicity and DNA damage can occur after thioguanine exposure Homo sapiens