Application | Comment | Organism |
---|---|---|
medicine | low enzyme level can lead to greater sensitivity to thiopurine therapy in astroglial cells | Mus musculus |
medicine | low enzyme level can lead to greater sensitivity to thiopurine therapy in astroglial cells | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Mus musculus | 5737 | - |
cytoplasm | - |
Homo sapiens | 5737 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-172 cell | - |
Homo sapiens | - |
astrocyte | primary cell | Mus musculus | - |
astroglial cell | - |
Mus musculus | - |
T-98 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + 6-mercaptopurine | - |
Mus musculus | S-adenosyl-L-homocysteine + 6-methylmercaptopurine | - |
? | |
S-adenosyl-L-methionine + 6-mercaptopurine | - |
Homo sapiens | S-adenosyl-L-homocysteine + 6-methylmercaptopurine | - |
? | |
S-adenosyl-L-methionine + thioguanine nucleotide | - |
Mus musculus | S-adenosyl-L-homocysteine + methylthioguanine | - |
? | |
S-adenosyl-L-methionine + thioguanine nucleotide | - |
Homo sapiens | S-adenosyl-L-homocysteine + methylthioguanine | - |
? | |
S-adenosyl-L-methionine + thioinosine monophosphate | - |
Mus musculus | S-adenosyl-L-homocysteine + methylthioinosine monophosphate | - |
? | |
S-adenosyl-L-methionine + thioinosine monophosphate | - |
Homo sapiens | S-adenosyl-L-homocysteine + methylthioinosine monophosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
thiopurine methyltransferase | - |
Mus musculus |
thiopurine methyltransferase | - |
Homo sapiens |
TPMT | - |
Mus musculus |
TPMT | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | when thiopurine methyltransferase protein activity is low a greater degree of cytotoxicity and DNA damage can occur after thioguanine exposure | Mus musculus |
malfunction | when thiopurine methyltransferase protein activity is low a greater degree of cytotoxicity and DNA damage can occur after thioguanine exposure | Homo sapiens |