Application | Comment | Organism |
---|---|---|
medicine | genetic variation in thiopurine S-methyltransferase is a major factor for wide variation in the metabolism and safety of thiopurine drugs | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | more than 20 variant alleles leading to deficient methylation phenotype have been described, four of them, TPMT*2, TPMT*3A, TPMT*3B and TPMT*3C, account for 80-95% of low activity alleles in various populations | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Homo sapiens | 5829 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
peripheral blood | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + 6-mercaptopurine | inactivation | Homo sapiens | S-adenosyl-L-homocysteine + 6-methylmercaptopurine | - |
? | |
S-adenosyl-L-methionine + 6-mercaptopurine nucleoside | inactivation | Homo sapiens | S-adenosyl-L-homocysteine + 6-methylmercaptopurine nucleoside | - |
? |
Synonyms | Comment | Organism |
---|---|---|
thiopurine S-methyltransferase | - |
Homo sapiens |
TMPT | - |
Homo sapiens |