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Literature summary for 2.1.1.67 extracted from

  • Slanar, O.; Bortlik, M.; Buzkova, H.; Donoval, R.; Pechandova, K.; Sebesta, I.; Lukas, M.; Perlik, F.
    Polymorphisms of the TPMT gene in the Czech healthy population and patients with inflammatory bowel disease (2008), Nucleosides Nucleotides Nucleic Acids, 27, 835-838.
    View publication on PubMed

Application

Application Comment Organism
medicine genetic variation in thiopurine S-methyltransferase is a major factor for wide variation in the metabolism and safety of thiopurine drugs Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information more than 20 variant alleles leading to deficient methylation phenotype have been described, four of them, TPMT*2, TPMT*3A, TPMT*3B and TPMT*3C, account for 80-95% of low activity alleles in various populations Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Homo sapiens 5829
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
peripheral blood
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + 6-mercaptopurine inactivation Homo sapiens S-adenosyl-L-homocysteine + 6-methylmercaptopurine
-
?
S-adenosyl-L-methionine + 6-mercaptopurine nucleoside inactivation Homo sapiens S-adenosyl-L-homocysteine + 6-methylmercaptopurine nucleoside
-
?

Synonyms

Synonyms Comment Organism
thiopurine S-methyltransferase
-
Homo sapiens
TMPT
-
Homo sapiens