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Literature summary for 2.1.1.67 extracted from

  • Taja-Chayeb, L.; Vidal-Millan, S.; Gutierrez, O.; Ostrosky-Wegman, P.; Duenas-Gonzalez, A.; Candelaria, M.
    Thiopurine S-methyltransferase gene (TMPT) polymorphisms in a Mexican population of healthy individuals and leukemic patients (2008), Med. Oncol., 25, 56-62.
    View publication on PubMed
Search for more literature for 2.1.1.67

Application

Application Comment Organism
medicine polymorphisms at the thiopurine S-methyltransferase coding gene determine enzyme activity and consequently, the development of toxicity secondary to thiopurines Homo sapiens

Protein Variants

Protein Variants Comment Organism
A154Y thiopurine S-methyltransferase polymorphism, G to A transition at position 460 Homo sapiens
A80P thiopurine S-methyltransferase polymorphism, G to C transition at position 238 Homo sapiens
Y240C thiopurine S-methyltransferase polymorphism, A to G transition at position 719 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + a thiopurine Homo sapiens
-
 S-adenosyl-L-homocysteine + a thiopurine S-methylether
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
leukocyte peripheral blood leukocytes Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + 6-mercaptopurine
-
 Homo sapiens ?
-
 ?
S-adenosyl-L-methionine + 6-thioguanine
-
 Homo sapiens ?
-
 ?
S-adenosyl-L-methionine + a thiopurine
-
 Homo sapiens S-adenosyl-L-homocysteine + a thiopurine S-methylether
-
 ?
S-adenosyl-L-methionine + azathioprine
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
thiopurine S-methyltransferase
-
 Homo sapiens
TMPT
-
 Homo sapiens