Application | Comment | Organism |
---|---|---|
diagnostics | thiopurine S-methyltransferase genotypes or phenotypes may be a predictive factor for azathioprine-induced toxicities | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
TPMT*2 | polymorphism, single nucleotide substitution, G238C at codon 80 | Homo sapiens |
TPMT*3A | polymorphism, single nucleotide substitutions, G460A at codon 154 and A719G at codon 240 | Homo sapiens |
TPMT*3B | polymorphism, single nucleotide substitution, G460A at codon 154 | Homo sapiens |
TPMT*3C | polymorphism, single nucleotide substitution, A719G at codon 240 | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + a thiopurine | Homo sapiens | - |
S-adenosyl-L-homocysteine + a thiopurine S-methylether | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + 6-mercaptopurine | - |
Homo sapiens | S-adenosyl-L-homocysteine + 6-methylmercaptopurine | - |
? | |
S-adenosyl-L-methionine + a thiopurine | - |
Homo sapiens | S-adenosyl-L-homocysteine + a thiopurine S-methylether | - |
? | |
S-adenosyl-L-methionine + azathioprine | azathioprine is converted via a non-enzymatic reaction to mercaptopurine, which is subsequently metabolized through TPMT | Homo sapiens | S-adenosyl-L-homocysteine + 6-methylmercaptopurine + ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
thiopurine S-methyltransferase | - |
Homo sapiens |
TPMT | - |
Homo sapiens |