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Literature summary for 2.1.1.67 extracted from
- Thiopurines inhibit bovine viral diarrhea virus production in a thiopurine methyltransferase-dependent manner (2008), J. Gen. Virol., 89, 1000-1009.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | the goal is to determine which metabolite of azathioprine has the most antiviral activity and to gain a better understanding of how this compound may act in vitro | Homo sapiens |
| medicine | the goal is to determine which metabolite of azathioprine has the most antiviral activity and to gain a better understanding of how this compound may act in vitro | Bos taurus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| Huh-7 cell | - |
Homo sapiens | - |
| MDBK cell | - |
Bos taurus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-methionine + 6-mercaptopurine | - |
Homo sapiens | S-adenosyl-L-homocysteine + 6-methylmercaptopurine | - |
? |  |
| S-adenosyl-L-methionine + 6-mercaptopurine | - |
Bos taurus | S-adenosyl-L-homocysteine + 6-methylmercaptopurine | - |
? | |
| S-adenosyl-L-methionine + 6-thioinosine | - |
Homo sapiens | S-adenosyl-L-homocysteine + 6-methylmercaptopurine riboside | - |
? | |
| S-adenosyl-L-methionine + 6-thioinosine | - |
Bos taurus | S-adenosyl-L-homocysteine + 6-methylmercaptopurine riboside | - |
? | |
| S-adenosyl-L-methionine + azathioprine | azathioprine is converted via a non-enzymatic reaction to mercaptopurine, which is subsequently metabolized through TPMT | Homo sapiens | S-adenosyl-L-homocysteine + 6-methylmercaptopurine + ? | - |
? | |
| S-adenosyl-L-methionine + azathioprine | azathioprine is converted via a non-enzymatic reaction to mercaptopurine, which is subsequently metabolized through TPMT | Bos taurus | S-adenosyl-L-homocysteine + 6-methylmercaptopurine + ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| thiopurine methyltransferase | - |
Homo sapiens |
| thiopurine methyltransferase | - |
Bos taurus |
| TPMT | - |
Homo sapiens |
| TPMT | - |
Bos taurus |
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Release 2023.1 (January 2023)
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