Application | Comment | Organism |
---|---|---|
medicine | the results suggest that coadministration of thiopurines and various nonsteriodal anti-inflammatory drugs may lead to drug interactions | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
celecoxib | - |
Homo sapiens | |
diclofenac | - |
Homo sapiens | |
flurbiprofen | - |
Homo sapiens | |
Ibuprofen | - |
Homo sapiens | |
Ketoprofen | - |
Homo sapiens | |
lornoxicam | - |
Homo sapiens | |
Mefenamic acid | - |
Homo sapiens | |
meloxicam | - |
Homo sapiens | |
nabumetone | - |
Homo sapiens | |
naproxen | - |
Homo sapiens | |
olsalazine | - |
Homo sapiens | |
paracetamol | - |
Homo sapiens | |
piroxicam | - |
Homo sapiens | |
tolfenamic acid | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + a thiopurine | Homo sapiens | - |
S-adenosyl-L-homocysteine + a thiopurine S-methylether | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
erythrocyte | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + 6-mercaptopurine | - |
Homo sapiens | S-adenosyl-L-homocysteine + 6-methylmercaptopurine | - |
? | |
S-adenosyl-L-methionine + 6-thioguanine | - |
Homo sapiens | S-adenosyl-L-homocysteine + 6-methylthioguanine | - |
? | |
S-adenosyl-L-methionine + a thiopurine | - |
Homo sapiens | S-adenosyl-L-homocysteine + a thiopurine S-methylether | - |
? | |
S-adenosyl-L-methionine + azathioprine | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
thiopurine S-methyltransferase | - |
Homo sapiens |
TPMT | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
TPMT activity assay | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
TPMT activity assay | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.039 | - |
Mefenamic acid | - |
Homo sapiens | |
0.05 | - |
tolfenamic acid | - |
Homo sapiens | |
0.052 | - |
naproxen | - |
Homo sapiens | |
0.172 | - |
Ketoprofen | - |
Homo sapiens | |
0.208 | - |
olsalazine | - |
Homo sapiens | |
0.722 | - |
diclofenac | - |
Homo sapiens | |
1.043 | - |
Ibuprofen | - |
Homo sapiens | |
1.41 | - |
lornoxicam | - |
Homo sapiens | |
1.524 | - |
flurbiprofen | - |
Homo sapiens | |
2.413 | - |
celecoxib | - |
Homo sapiens | |
2.589 | - |
piroxicam | - |
Homo sapiens | |
4.238 | - |
meloxicam | - |
Homo sapiens | |
4.3 | - |
nabumetone | - |
Homo sapiens | |
5.162 | - |
paracetamol | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.039 | - |
- |
Homo sapiens | Mefenamic acid | |
0.063 | - |
- |
Homo sapiens | tolfenamic acid | |
0.079 | - |
- |
Homo sapiens | naproxen | |
1.013 | - |
- |
Homo sapiens | Ketoprofen | |
1.474 | - |
- |
Homo sapiens | olsalazine | |
1.582 | - |
- |
Homo sapiens | diclofenac | |
1.649 | - |
- |
Homo sapiens | flurbiprofen | |
1.968 | - |
- |
Homo sapiens | Ibuprofen | |
2.135 | - |
- |
Homo sapiens | lornoxicam | |
2.416 | - |
- |
Homo sapiens | celecoxib | |
2.589 | - |
- |
Homo sapiens | piroxicam | |
4.292 | - |
- |
Homo sapiens | meloxicam | |
4.341 | - |
- |
Homo sapiens | nabumetone | |
5.168 | - |
- |
Homo sapiens | paracetamol |