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Literature summary for 2.1.1.67 extracted from

  • Gardiner, S.J.; Gearry, R.B.; Begg, E.J.; Zhang, M.; Barclay, M.L.
    Thiopurine dose in intermediate and normal metabolizers of thiopurine methyltransferase may differ three-fold (2008), Clin. Gastroenterol. Hepatol., 6; 654-60, quiz 604.
    View publication on PubMed
Search for more literature for 2.1.1.67

Application

Application Comment Organism
medicine patients with inflammatory bowel disease may have different thiopurine dose requirements in relation to thiopurine methyltransferase genotype or phenotype Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + a thiopurine Homo sapiens
-
 S-adenosyl-L-homocysteine + a thiopurine S-methylether
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood
-
 Homo sapiens
-
erythrocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + 6-mercaptopurine
-
 Homo sapiens S-adenosyl-L-homocysteine + 6-methylmercaptopurine
-
 ?
S-adenosyl-L-methionine + 6-thioguanine monophosphate
-
 Homo sapiens S-adenosyl-L-homocysteine + 6-methylthioguanine monophosphate
-
 ?
S-adenosyl-L-methionine + 6-thioinosine monophosphate
-
 Homo sapiens S-adenosyl-L-homocysteine + 6-methylthioinosine monophosphate
-
 ?
S-adenosyl-L-methionine + a thiopurine
-
 Homo sapiens S-adenosyl-L-homocysteine + a thiopurine S-methylether
-
 ?

Synonyms

Synonyms Comment Organism
thiopurine methyltransferase
-
 Homo sapiens
TPMT
-
 Homo sapiens