Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.1.1.67 extracted from

  • Palmieri, O.; Latiano, A.; Bossa, F.; Vecchi, M.; DInca, R.; Guagnozzi, D.; Tonelli, F.; Cucchiara, S.; Valvano, M.R.; Latiano, T.; Andriulli, A.; Annese, V.
    Sequential evaluation of thiopurine methyltransferase, inosine triphosphate pyrophosphatase, and HPRT1 genes polymorphisms to explain thiopurines toxicity and efficacy (2007), Aliment. Pharmacol. Ther., 26, 737-745.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
A154T variant TPMT*3B, G460A polymorphismus Homo sapiens
Y240C variant TPMT*3C, A719G polymorphismus Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + a thiopurine Homo sapiens
-
S-adenosyl-L-homocysteine + a thiopurine S-methylether
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
leukocyte peripheral blood leukocytes Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + 6-mercaptopurine azathioprine is converted via a non-enzymatic reaction to mercaptopurine, which is subsequently metabolized through TPMT Homo sapiens S-adenosyl-L-homocysteine + 6-methylmercaptopurine
-
?
S-adenosyl-L-methionine + a thiopurine
-
Homo sapiens S-adenosyl-L-homocysteine + a thiopurine S-methylether
-
?

Synonyms

Synonyms Comment Organism
thiopurine methyltransferase
-
Homo sapiens