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Literature summary for 2.1.1.63 extracted from
- A radioisotope-nondependent high-sensitivity method for measuring the activity of glioblastoma-related O6-methylguanine DNA methyltransferase (2015), Anal. Biochem., 480, 82-84.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| O6-benzylguanine | - |
Homo sapiens |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| DNA (containing 6-O-methylguanine) + protein L-cysteine | Homo sapiens | - |
DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| A-431 cell | - |
Homo sapiens | - |
| glioblastoma cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| DNA (containing 6-O-methylguanine) + protein L-cysteine | - |
Homo sapiens | DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| MGMT | - |
Homo sapiens |
| O6-methylguanine DNA methyltransferase | - |
Homo sapiens |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.0004 | - |
at pH 7.5 and 37°C | Homo sapiens | O6-benzylguanine | |
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Release 2023.1 (January 2023)
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