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Literature summary for 2.1.1.63 extracted from

  • Parkinson, J.; Wheeler, H.; Clarkson, A.; McKenzie, C.; Biggs, M.; Little, N.; Cook, R.; Messina, M.; Robinson, B.; McDonald, K.
    Variation of O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation in serial samples in glioblastoma (2008), J. Neurooncol., 87, 71-78.
    View publication on PubMed
Search for more literature for 2.1.1.63

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
glioblastoma cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA containing 6-O-methylguanine + [protein]-L-cysteine
-
 Homo sapiens DNA lacking 6-O-methylguanine + [protein]-S-methyl-L-cysteine
-
 ?

Synonyms

Synonyms Comment Organism
MGMT
-
 Homo sapiens
O6-methylguanine-DNA methyltransferase
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens there is a good correlation between the increasing MGMT promoter methylation and decreased MGMT expression, in most patients who has been treated with temozolomide, there is decreased MGMT expression in the post treatment sample when compared to the primary sample down