Literature summary for 2.1.1.63 extracted from

Schwarzl, S.M.; Smith, J.C.; Kaina, B.; Efferth, T.
Molecular modeling of O6-methylguanine-DNA methyltransferase mutant proteins encoded by single nucleotide polymorphisms (2005), Int. J. Mol. Med., 16, 553-557.

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Protein Variants

Protein Variants	Comment	Organism
A121E	no major structural change upon energy minimization, is within the DNA binding region and may therefore affect DNA binding of MGMT	Homo sapiens
A121T	no major structural change upon energy minimization, is within the DNA binding region and may therefore affect DNA binding of MGMT	Homo sapiens
E166D	no major structural change upon energy minimization	Homo sapiens
G132R	no major structural change upon energy minimization, is within the DNA binding region and may therefore affect DNA binding of MGMT	Homo sapiens
G160R	no major structural change upon energy minimization, is in the vicinity of the active Cys145 and may cause disturbances of O6-alkyl transfer from DNA to the protein	Homo sapiens
I143V	no major structural change upon energy minimization, is in the vicinity of the active Cys145 and may cause disturbances of O6-alkyl transfer from DNA to the protein, does not affect DNA repair capacity	Homo sapiens
L84F	no major structural change upon energy minimization, may affect Zn2+ binding, does not affect DNA repair capacity	Homo sapiens
additional information	examination of the structural changes accompanying single nucleotide polymorphisms-related amino-acid changes in the MGMT protein	Homo sapiens
N123V	no major structural change upon energy minimization, is within the DNA binding region and may therefore affect DNA binding of MGMT	Homo sapiens
W65C	no major structural change upon energy minimization, possibly unstable	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P16455	-	-

Synonyms

Synonyms	Comment	Organism
MGMT	-	Homo sapiens
O6-methylguanine-DNA methyltransferase	-	Homo sapiens

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Release 2023.1 (January 2023)