Application | Comment | Organism |
---|---|---|
medicine | the enzyme is important in cellular resistance to certain alkylating antitumor agents such as the methylating drug temozolomide. Cisplatin is able to decrease enzyme levels in Jurkat cells, probably via the inhibition of gene transcription. The clinical efficiacy of triazene compounds might be improved by combination with cisplatin using appropriate doses and schedules of administration | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
JURKAT cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
DNA containing 6-O-methylguanine + [protein]-L-cysteine | - |
Homo sapiens | DNA lacking 6-O-methylguanine + [protein]-S-methyl-L-cysteine | - |
? |