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Literature summary for 2.1.1.63 extracted from

  • D'Atri, S.; Graziani, G.; Lacal, P.M.; Nistico, V.; Gilberti, S.; Faraoni, I.; Watson, A.J.; Bonmassar, E.; Margison, G.P.
    Attenuation of O(6)-methylguanine-DNA methyltransferase activity and mRNA levels by cisplatin and temozolomide in jurkat cells (2000), J. Pharmacol. Exp. Ther., 294, 664-671.
    View publication on PubMed

Application

Application Comment Organism
medicine the enzyme is important in cellular resistance to certain alkylating antitumor agents such as the methylating drug temozolomide. Cisplatin is able to decrease enzyme levels in Jurkat cells, probably via the inhibition of gene transcription. The clinical efficiacy of triazene compounds might be improved by combination with cisplatin using appropriate doses and schedules of administration Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
JURKAT cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA containing 6-O-methylguanine + [protein]-L-cysteine
-
Homo sapiens DNA lacking 6-O-methylguanine + [protein]-S-methyl-L-cysteine
-
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