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Literature summary for 2.1.1.60 extracted from

  • Magen, S.; Magnani, R.; Haziza, S.; Hershkovitz, E.; Houtz, R.; Cambi, F.; Parvari, R.
    Human calmodulin methyltransferase: expression, activity on calmodulin, and Hsp90 dependence (2012), PLoS ONE, 7, e52425.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.60

Cloned(Commentary)

Cloned (Comment) Organism
expressed in COS-7 cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Mus musculus 5737
-
cytoplasm
-
 Homo sapiens 5737
-
Golgi apparatus
-
 Mus musculus 5794
-
Golgi apparatus short isoform Homo sapiens 5794
-
nucleus
-
 Mus musculus 5634
-
nucleus
-
 Homo sapiens 5634
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
36000
-
 x * 36000, SDS-PAGE Mus musculus
36000
-
 x * 36000, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + calmodulin L-lysine Mus musculus
-
 S-adenosyl-L-homocysteine + calmodulin N6-methyl-L-lysine
-
 ?
S-adenosyl-L-methionine + calmodulin L-lysine Homo sapiens
-
 S-adenosyl-L-homocysteine + calmodulin N6-methyl-L-lysine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q7Z624
-
-
Mus musculus Q3U2J5
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-
HEK-293 cell
-
 Homo sapiens
-
HeLa cell
-
 Homo sapiens
-
muscle
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + calmodulin L-lysine
-
 Mus musculus S-adenosyl-L-homocysteine + calmodulin N6-methyl-L-lysine
-
 ?
S-adenosyl-L-methionine + calmodulin L-lysine
-
 Homo sapiens S-adenosyl-L-homocysteine + calmodulin N6-methyl-L-lysine
-
 ?

Subunits

Subunits Comment Organism
? x * 36000, SDS-PAGE Mus musculus
? x * 36000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
calmodulin methyltransferase
-
 Mus musculus
calmodulin methyltransferase
-
 Homo sapiens
CaM KMT
-
 Mus musculus
CaM KMT previously C2orf34 Homo sapiens

General Information

General Information Comment Organism
malfunction the absence of enzyme causes accumulation of hypomethylated calmodulin in 2p21 deletion syndrome patients Homo sapiens
metabolism the enzyme is the major methyltransferase of calmodulin in human cells and a Hsp90 client protein Homo sapiens